257494

Sigma-Aldrich

3-Cyano-PROXYL

for ESR-spectroscopy

Synonym(s):
3-Cyano-2,2,5,5-tetramethyl-1-pyrrolidinyloxy, free radical
Empirical Formula (Hill Notation):
C9H15N2O
CAS Number:
Molecular Weight:
167.23
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

grade

for ESR-spectroscopy

Quality Level

mp

31-33 °C (lit.)

storage temp.

2-8°C

SMILES string

CC1(C)CC(C#N)C(C)(C)N1[O]

InChI

1S/C9H15N2O/c1-8(2)5-7(6-10)9(3,4)11(8)12/h7H,5H2,1-4H3

InChI key

RQRRZZIMMXPAGX-UHFFFAOYSA-N

General description

Spin label

Application

3-Cyano-PROXYL is a stable free radical that can be used in the ESR technique as a nitroxide standard:
  • For the estimation of relative concentrations of the spin adducts of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) with ·OH and O2.- radicals.
  • For the determination of free radicals present in an aqueous cigarette tar extract.

Packaging

25 mg in clear glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Scavenging of superoxide anion radical by chaparral
Zang L-Y, et al.
Molecular and Cellular Biochemistry, 196(1-2), 157-161 (1999)
Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance
Zang L-Y, et al.
Free radical biology & medicine, 19(2), 161-167 (1995)
Effect of chlorogenic acid on hydroxyl radical
Zhang L-Y, et al.
Molecular and Cellular Biochemistry, 247(1-2), 205-210 (2003)
S M Hahn et al.
Radiation research, 132(1), 87-93 (1992-10-01)
The nitroxide Tempol, a stable free radical, has recently been shown to protect mammalian cells against several forms of oxidative stress including radiation-induced cytotoxicity. To extend this observation, six additional water-soluble nitroxides with different structural features were evaluated for potential...

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