259187

Sigma-Aldrich

Hexetidine, mixture of stereoisomers

Synonym(s):
NSC 17764, 5-Amino-1,3-bis(2-ethylhexyl)hexahydro-5-methylpyrimidine
Empirical Formula (Hill Notation):
C21H45N3
CAS Number:
Molecular Weight:
339.60
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

refractive index

n20/D 1.4649 (lit.)

bp

160 °C/0.4 mmHg (lit.)

solubility

acetone: soluble(lit.)
benzene: soluble(lit.)
chloroform: soluble(lit.)
ethanol: soluble(lit.)
hexane: soluble(lit.)
methanol: soluble(lit.)
petroleum ether: soluble(lit.)
water: insoluble(lit.)

density

0.889 g/mL at 25 °C (lit.)

SMILES string

CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1

InChI

1S/C21H45N3/c1-6-10-12-19(8-3)14-23-16-21(5,22)17-24(18-23)15-20(9-4)13-11-7-2/h19-20H,6-18,22H2,1-5H3

InChI key

DTOUUUZOYKYHEP-UHFFFAOYSA-N

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General description

The effectiveness of a hexetidine mouthwash in reducing supragingival plaque and gingival inflammation has been examined.

Application

Involved in studies:
  • To identify pure liquid salt forms of aspirin
  • Of alkyl based selective displacers for protein purification via ion exchange chromatography
  • Of the in vivo application of models for testing drugs against nonreplicating Mycobacterium tuberculosis
  • Nutrient-sensitized screening for drugs that shift the energy metabolism from mitochondrial respiration to glycolysis
  • Inhibition of angiogensis
  • Screening antimalarial drugs

Packaging

10 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 259187.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

WGK Germany

WGK 3

David S Jones et al.
Pharmaceutical research, 19(6), 818-824 (2002-07-24)
Ventilator-associated pneumonia is a frequent cause of mortality in intensive care patients. This study describes the physicochemical properties of hexetidine-impregnated poly(vinyl chloride) (PVC) endotracheal tube (ET) biomaterials and their resistance to microbial adherence (Staphylococcus aureus and Pseudomonas aeruginosa). PVC emulsion...
M Koray et al.
Oral diseases, 11(5), 309-313 (2005-08-27)
The aim of the present study was to compare the influence of fluconazole capsules and/or hexetidine mouthrinses for the management of oral candidiasis associated with denture stomatitis. DESIGN RELEVANT: Sixty-one patients (ages 43-76 years, mean: 61) admitted to the Department...
Claus-Peter Ernst et al.
Quintessence international (Berlin, Germany : 1985), 36(8), 641-652 (2005-09-16)
The aim of this clinical, controlled double-blind trial was to evaluate the effectiveness and side effects of two different mouthrinses. Ninety subjects with gingivitis (or slight periodontitis) were randomly allocated to three groups: group 1, Chlorhexamed (0.1% chlorhexidine); group 2...
M Martin et al.
Der Anaesthesist, 61(1), 25-29 (2012-01-26)
A total of three intensive care units (ICU) at a German university hospital were involved in an outbreak of Burkholderia cepacia complex (Bcc). Patients with microbiological detection of Bcc were evaluated. Products used for mouth hygiene were microbiologically tested. The...
N L Kunel'skaia et al.
Vestnik otorinolaringologii, (2)(2), 62-66 (2008-05-06)
A pilot trial of efficacy of the drugs lisobact and stomatidin in local treatment of acute pharyngitis and combined therapy of tonsillitis and paratonsillar abscess included 82 patients with tonsillitis (n=30), paratonsillar abscess (n=30) and acute pharyngitis (n=22) aged 15-72...

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