Hexetidine, mixture of stereoisomers

NSC 17764, 5-Amino-1,3-bis(2-ethylhexyl)hexahydro-5-methylpyrimidine
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
EC Number:
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PubChem Substance ID:

Quality Level

refractive index

n20/D 1.4649 (lit.)


160 °C/0.4 mmHg (lit.)


acetone: soluble(lit.)
benzene: soluble(lit.)
chloroform: soluble(lit.)
ethanol: soluble(lit.)
hexane: soluble(lit.)
methanol: soluble(lit.)
petroleum ether: soluble(lit.)
water: insoluble(lit.)


0.889 g/mL at 25 °C (lit.)

SMILES string




InChI key


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General description

The effectiveness of a hexetidine mouthwash in reducing supragingival plaque and gingival inflammation has been examined.


Involved in studies:
  • To identify pure liquid salt forms of aspirin
  • Of alkyl based selective displacers for protein purification via ion exchange chromatography
  • Of the in vivo application of models for testing drugs against nonreplicating Mycobacterium tuberculosis
  • Nutrient-sensitized screening for drugs that shift the energy metabolism from mitochondrial respiration to glycolysis
  • Inhibition of angiogensis
  • Screening antimalarial drugs


10 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 259187.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.


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Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

WGK Germany


Certificate of Analysis

Certificate of Origin

David S Jones et al.
Pharmaceutical research, 19(6), 818-824 (2002-07-24)
Ventilator-associated pneumonia is a frequent cause of mortality in intensive care patients. This study describes the physicochemical properties of hexetidine-impregnated poly(vinyl chloride) (PVC) endotracheal tube (ET) biomaterials and their resistance to microbial adherence (Staphylococcus aureus and Pseudomonas aeruginosa). PVC emulsion...
M Koray et al.
Oral diseases, 11(5), 309-313 (2005-08-27)
The aim of the present study was to compare the influence of fluconazole capsules and/or hexetidine mouthrinses for the management of oral candidiasis associated with denture stomatitis. DESIGN RELEVANT: Sixty-one patients (ages 43-76 years, mean: 61) admitted to the Department...
N L Kunel'skaia et al.
Vestnik otorinolaringologii, (2)(2), 62-66 (2008-05-06)
A pilot trial of efficacy of the drugs lisobact and stomatidin in local treatment of acute pharyngitis and combined therapy of tonsillitis and paratonsillar abscess included 82 patients with tonsillitis (n=30), paratonsillar abscess (n=30) and acute pharyngitis (n=22) aged 15-72...
M Martin et al.
Der Anaesthesist, 61(1), 25-29 (2012-01-26)
A total of three intensive care units (ICU) at a German university hospital were involved in an outbreak of Burkholderia cepacia complex (Bcc). Patients with microbiological detection of Bcc were evaluated. Products used for mouth hygiene were microbiologically tested. The...
Claus-Peter Ernst et al.
Quintessence international (Berlin, Germany : 1985), 36(8), 641-652 (2005-09-16)
The aim of this clinical, controlled double-blind trial was to evaluate the effectiveness and side effects of two different mouthrinses. Ninety subjects with gingivitis (or slight periodontitis) were randomly allocated to three groups: group 1, Chlorhexamed (0.1% chlorhexidine); group 2...

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