259322

Sigma-Aldrich

Chloroacetyl isocyanate

≥95%

Linear Formula:
ClCH2CONCO
CAS Number:
Molecular Weight:
119.51
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

≥95%

refractive index

n20/D 1.463 (lit.)

bp

50-55 °C/20 mmHg (lit.)

density

1.403 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

ClCC(=O)N=C=O

InChI

1S/C3H2ClNO2/c4-1-3(7)5-2-6/h1H2

InChI key

MOVMEFHWBOWMFU-UHFFFAOYSA-N

Application

Chloroacetyl isocyanate has been used in the synthesis of:
  • fumagillin analogs
  • 2-chloro-N-(4-oxocyclopent-2-enyl)-acetamide

Packaging

1, 5 g in glass bottle

Signal Word

Danger

Hazard Statements

Supp Hazards

EUH014

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

T

Risk Statement

14-25-34-42

Safety Statement

26-36/37/39-45

RIDADR

UN 2922 6.1(8) / PGII

WGK Germany

WGK 3

Flash Point(F)

143.6 °F - closed cup

Flash Point(C)

62 °C - closed cup

Ralph Mazitschek et al.
Organic & biomolecular chemistry, 3(11), 2150-2154 (2005-05-27)
A promising approach among the numerous efforts to cure cancer is the interruption of the tumour-induced formation of new blood vessels (angiogenesis). By suppressing angiogenesis with drugs, the tumour can neither grow to a life threatening size, nor metastasize. The...
Synthesis of 4-azacyclopent-2-enones and 5, 5-dialkyl-4-azacyclopent-2-enones.
Dauvergne J, et al.
Tetrahedron, 60(11), 2559-2567 (2004)

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