261610

Sigma-Aldrich

Cyanogen bromide solution

5.0 M in acetonitrile

Linear Formula:
BrCN
CAS Number:
Molecular Weight:
105.92
Beilstein/REAXYS Number:
1697296
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

concentration

5.0 M in acetonitrile

solubility

alcohol: freely soluble(lit.)
diethyl ether: freely soluble(lit.)
water: freely soluble(lit.)

density

1.093 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

BrC#N

InChI

1S/CBrN/c2-1-3

InChI key

ATDGTVJJHBUTRL-UHFFFAOYSA-N

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General description

Cyanogen bromide solution induces template-guided condensation of oligonucleotides only in the presence of N-substituted morpholines. Mechanism of the phosphomonoester group activation by cyanogen bromide in N-substituted morpholine buffers has been investigated.

Application

Cyanogen bromide is a general reagent used to cleave carbon-heteroatom bonds. It is used in the synthesis of organocyanamides from corresponding tertiary amines, which is popularly known as von Braun reaction. CNBr solution is widely used in protein immobilization and cleavage.

Packaging

100 mL in Sure/Seal™

Signal Word

Danger

Supp Hazards

EUH032

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN3489 - class 6.1 - PG 1 - EHS - MP - RQ - acidic - Toxic by inhalation liquid, flammable, corrosive, n.o.s., HI: all (not BR)

WGK Germany

WGK 3

Flash Point(F)

42.8 °F - closed cup

Flash Point(C)

6 °C - closed cup

Certificate of Analysis
Certificate of Origin
Wen Qian et al.
Scientific reports, 10(1), 6470-6470 (2020-04-15)
The conjugation of polysaccharides with an effective carrier protein is critical for the development of effective bacterial polysaccharide vaccines. Therefore, the identification and optimization of carrier proteins to induce an effective immune response is necessary for developing a combined vaccine....
Cyanogen Bromide.
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
Bromalkylierte aromatische Amine. II. Mitteilung.
v Braun J, et al.
Ber. Deutsch. Chem. Ges., 51, 273-282 (1918)
Immobilization of lipases on hydrophobic supports involves the open form of the enzyme.
Manoel EA, et al.
Enz. Microbiol. Technol., 71, 53-57 (2015)
Z A Shabarova et al.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 27(5-6), 555-566 (2001-09-07)
Cyanogen bromide has been found to induce the template-guided condensation of oligonucleotides only in the presence of N-substituted morpholines. Based on 31P, 1H and 13C NMR spectroscopy data, the mechanism of the phosphomonoester group activation by cyanogen bromide in N-substituted...

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