26569

Sigma-Aldrich

2-Chlorotrityl chloride

≥97.0% (AT)

Synonym(s):
Chloro(2-chlorophenyl)diphenylmethane
Empirical Formula (Hill Notation):
C19H14Cl2
CAS Number:
Molecular Weight:
313.22
Beilstein/REAXYS Number:
1983914
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

≥97.0% (AT)

mp

130-135 °C

SMILES string

Clc1ccccc1C(Cl)(c2ccccc2)c3ccccc3

InChI

1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H

Inchi Key

JFLSOKIMYBSASW-UHFFFAOYSA-N

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Application

2-Chlorotrityl chloride was used to obtain protected peptide fragments that can be applied to the preparation of head-to-tail cyclopeptides or to condensation of peptidic fragments.

Packaging

10 g in poly bottle

Other Notes

Protecting group reagent for carboxylic acids forming esters which are cleaved mildly.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Shinichiro F Ichise et al.
Acta biomaterialia, 94, 361-371 (2019-06-15)
Collagen is the most abundant protein in the animal kingdom and has a unique triple-helical structure. It not only provides mechanical strength to tissues, but also performs specific biological functions as a multifaceted signaling molecule. Animal-derived collagen is therefore widely...
K Barlos et al.
International journal of peptide and protein research, 37(6), 513-520 (1991-06-01)
The esterification of 2-chlorotrityl chloride resin with Fmoc-amino acids in the presence of DIEA is studied under various conditions. High esterification yields are obtained using 0.6 equiv. Fmoc-amino acid/mmol resin in DCM or DCE, in 25 min, at room temperature....
Jie Luo et al.
Journal of the American Society for Mass Spectrometry, 30(9), 1643-1653 (2019-06-07)
Chemical cross-linking combined with mass spectrometry (CL-MS) is a powerful method for characterizing the architecture of protein assemblies and for mapping protein-protein interactions. Despite its proven utility, confident identification of cross-linked peptides remains a formidable challenge, especially when the peptides...
P. Athanassopoulos et al.
Tetrahedron Letters, 36, 5645-5645 (1995)
Elżbieta Kamysz et al.
Journal of peptide science : an official publication of the European Peptide Society, 18(9), 560-566 (2012-07-13)
LL37 and histatin 5 are antimicrobial peptides. LL37 exhibits killing activity against a broad spectrum of pathogens, whereas histatin 5 is primarily an antifungal agent. Head-to-tail cyclization of histatin 5 did not affect its antimicrobial and haemolytic activity. The cyclic...

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