There is no information indicating that this product is susceptible to oxidation or that it should be handled and stored in a glove box. According to PubChem, this product is a natural compound with widespread protective effects, including anti-oxidative, anti-inflammatory, immunomodulatory, anti-cancer, and anti-microbial properties.
274666
Thymoquinone
≥98%
Synonym(s):
2-Isopropyl-5-methyl-1,4-benzoquinone
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$68.30
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$213.00
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About This Item
Empirical Formula (Hill Notation):
C10H12O2
CAS Number:
Molecular Weight:
164.20
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
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Quality Level
assay
≥98%
form
solid
technique(s)
titration: suitable
color
yellow
bp
230-232 °C (lit.)
mp
45-47 °C (lit.)
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
CC(C)C1=CC(=O)C(C)=CC1=O
InChI
1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3
InChI key
KEQHJBNSCLWCAE-UHFFFAOYSA-N
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Related Categories
1 of 4
This Item | 1667111 | 271993 | 03416 |
|---|---|---|---|
| technique(s) titration: suitable | technique(s) - | technique(s) - | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| color yellow | color - | color - | color - |
| application(s) diagnostic assay manufacturing | application(s) pharmaceutical | application(s) diagnostic assay manufacturing | application(s) cleaning products |
| form solid | form - | form powder, crystals or chunks | form - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. room temp | storage temp. - |
| assay ≥98% | assay - | assay - | assay ≥98.5% (GC) |
General description
Thymoquinone (TQ), also known as 2-isopropyl-5-methyl-1, 4-benzoquinone, is present in a crystalline triclinic form. It is the bioactive constituent of the volatile oil of black seed. TQ exhibits anti-inflammatory, antioxidant and anti-neoplastic effects both in vitro and in vivo.[1]
Application
Thymoquinone has been used as an inhibitor of Escherichia coli ATP synthase and cell growth. It is also used as a drug against lower limb ischemia-reperfusion injury of the sciatic nerve and femoral muscle.[2]
Thymoquinone is employed in preclinical studies as a neuroprotective and anticonvulsant agent.
[2]
Thymoquinone is employed in preclinical studies as a neuroprotective and anticonvulsant agent.
[2]
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
219.2 °F - closed cup
flash_point_c
104 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Samir Attoub et al.
Fundamental & clinical pharmacology, 27(5), 557-569 (2012-07-14)
Phytochemical compounds are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. The purpose of this study was to investigate the potential impact of thymoquinone (TQ), the major constituent of black seed, on survival, invasion
Inna I Severina et al.
FEBS letters, 587(13), 2018-2024 (2013-05-15)
Since the times of the Bible, an extract of black cumin seeds was used as a medicine to treat many human pathologies. Thymoquinone (2-demethylplastoquinone derivative) was identified as an active antioxidant component of this extract. Recently, it was shown that
Anjali Singh et al.
Colloids and surfaces. B, Biointerfaces, 102, 822-832 (2012-10-30)
This research aims to formulate and characterize solid lipid nanoparticles (SLNs) of Thymoquinone (THQ-SLNs) for the effective treatment of liver cirrhosis. Formulations were prepared using solvent injection method and optimized by the Box-Behnken experimental design to get the desired particle
Thymoquinone: A promising anti-cancer drug from natural sources
Gali-Muhtasib H
The International Journal of Biochemistry & Cell Biology, 38, 1249-1253 (2006)
Hala Gali-Muhtasib et al.
The international journal of biochemistry & cell biology, 38(8), 1249-1253 (2005-11-30)
There has been growing interest in naturally occurring compounds with anti-cancer potential. Black seed is one of the most extensively studied plants. This annual herb grows in countries bordering the Mediterranean Sea and India. Thymoquinone (TQ) is the bioactive constituent
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Is this powder susceptible to oxidation? Should it be opened in a glove box?
1 answer-
Helpful?
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Can this substance be used for loading into liposomes?
1 answer-
This product has not been tested specifically for liposomal delivery systems. As such, we would refer to the academic literature to see if similar experiments utilizing thymoquinone have successfully been loaded into liposomes.
Helpful?
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Hello I've bought 1 gram of Thymoquinone (product number: 274666) and I wanna use this in different concenteration for MTT assay. Could you please tell me that in which solvent I should dissolve the powder and How can I dillute it with PBS?
1 answer-
The solubility of this product is not determined. For analytical purposes, the material is heated to form a liquid and is tested in the neat form. Various sources indicate that this compound is soluble in DMSO, DMF, and Ethanol. Please see the link below to review a publication that indicates stock solutions may then be further diluted in phosphate buffer:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270770/Helpful?
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