279072

Sigma-Aldrich

Cyproheptadine hydrochloride sesquihydrate

99%

Synonym(s):
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine hydrochloride hydrate
Empirical Formula (Hill Notation):
C21H21N · HCl · 1.5H2O
CAS Number:
Molecular Weight:
350.88
EC Number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

99%

mp

165 °C (dec.) (lit.)

solubility

1 M NH4OH: soluble 25 mg/mL, clear, colorless to faintly yellow

SMILES string

O.O.O.Cl.CN1CCC(\CC1)=C2\c3ccccc3C=Cc4ccccc24.CN5CCC(\CC5)=C6\c7ccccc7C=Cc8ccccc68

InChI

1S/2C21H21N.ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;/h2*2-11H,12-15H2,1H3;1H;3*1H2

InChI key

PXCSXCDWTUPVIM-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine. It induced preventive effect against the development of pergolide-induced valvulopathy in a rat model.

Application

Structural studies of an antihistimine

Packaging

5 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

The structure of an antihistamine: cyproheptadine hydrochloride sesquihydrate.
Birknes BJORN.
Acta Crystallographica Section B, Structural Science, 33(3), 687-691 (1977)
Steven Droogmans et al.
American journal of physiology. Heart and circulatory physiology, 296(6), H1940-H1948 (2009-04-07)
Serotonergic drugs, such as pergolide, have been associated with the development of cardiac valvular myxoid thickening and regurgitation in humans and more recently in rats. These effects are potentially mediated by the 5-hydroxytryptamine (5-HT)(2B) receptor (5-HT(2B)R). Therefore, we sought to...
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.