279552

Sigma-Aldrich

4-Chloro-3-ethylphenol

97%

Linear Formula:
ClC6H3(C2H5)OH
CAS Number:
Molecular Weight:
156.61
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

97%

mp

45-50 °C (lit.)

SMILES string

CCc1cc(O)ccc1Cl

InChI

1S/C8H9ClO/c1-2-6-5-7(10)3-4-8(6)9/h3-5,10H,2H2,1H3

InChI key

DVKVZPIRWWREJC-UHFFFAOYSA-N

Related Categories

Application

4-Chloro-3-ethylphenol is a ryanodine receptor antagonist and is commonly used as research tool and diagnostic reagent for malignant hyperthermia.

Packaging

25 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Certificate of Analysis
Certificate of Origin
M U Gerbershagen et al.
European journal of anaesthesiology, 19(2), 135-140 (2002-05-10)
The in vitro contracture test with halothane and caffeine is the current gold standard for diagnosis of malignant hyperthermia. This test has a sensitivity of 99.0% but a specificity of only 93.6%. Therefore, an alternative drug is desirable which distinguishes...
A M Low et al.
British journal of pharmacology, 122(3), 504-510 (1997-11-14)
1. Recently, 4-chloro-3-ethyl phenol (CEP) has been shown to cause the release of internally stored Ca2+ apparently through ryanodine-sensitive Ca2+ channels, in fractionated skeletal muscle terminal cisternae and in a variety of non-excitable cell types. Its action on smooth muscle...
Bo Zeng et al.
British journal of pharmacology, 171(5), 1250-1259 (2014-03-29)
Depletion of the Ca(2+) store by ryanodine receptor (RyR) agonists induces store-operated Ca(2+) entry (SOCE). 4-Chloro-3-ethylphenol (4-CEP) and 4-chloro-m-cresol (4-CmC) are RyR agonists commonly used as research tools and diagnostic reagents for malignant hyperthermia. Here, we investigated the effects of...
Francisco H Andrade et al.
Investigative ophthalmology & visual science, 46(12), 4541-4547 (2005-11-24)
The ultrafast extraocular muscles necessitate tight regulation of free cytosolic Ca2+ concentration ([Ca2+]i). Mitochondrial Ca2+ influx may be fast enough for this role. In the present study, three hypotheses were tested: (1) Mitochondrial Ca2+ uptake regulates [Ca2+]i and production of...
C Y Kwan et al.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 20(5), 385-390 (2000-05-20)
To study the spatial and temporal distribution of intracellular Ca2+ concentration in cultured bovine pulmonary artery endothelial (BPAE) cells. Cultured BPAE cells were loaded with Fura-2 and observed under an inverted microscope coupled to a microfluorimeter, which enables pixel-to-pixel ratio...

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