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MilliporeSigma

282227

Chlorhexidine

≥99.5%

Synonym(s):

1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide]

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About This Item

Linear Formula:
[-(CH2)3NHC(=NH)NHC(=NH)NHC6H4Cl]2
CAS Number:
55-56-1
Molecular Weight:
505.45
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24857031
EC Number:
200-238-7
Beilstein/REAXYS Number:
2826432
MDL number:
MFCD00009673
Assay:
≥99.5%
Form:
powder

Key Documents

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InChI key

GHXZTYHSJHQHIJ-UHFFFAOYSA-N

InChI

1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)

SMILES string

Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

assay

≥99.5%

form

powder

impurities

<1.0% water

Quality Level

100

solubility

water: soluble 0.08% at 20 °C

functional group

amine, chloro

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1 of 4

This Item
PHR14211111001C1510000
Chlorhexidine &#8805;99.5%

Sigma-Aldrich

282227

Chlorhexidine

Chlorhexidine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1421

Chlorhexidine

Chlorhexidine United States Pharmacopeia (USP) Reference Standard

USP

1111001

Chlorhexidine

Chlorhexidine European Pharmacopoeia (EP) Reference Standard

C1510000

Chlorhexidine

assay

≥99.5%

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

solubility

water: soluble 0.08% at 20 °C

solubility

-

solubility

-

solubility

-

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

form

powder

form

-

form

-

form

-

impurities

<1.0% water

impurities

-

impurities

-

impurities

-

General description

Effect of the chlorhexidine:hydroxypropyl-β-cyclodextrin inclusion compound on in vitro slabs of bovine dentine has been investigated[1].

Chlorhexidine is a cationic surfactant with broad-spectrum antimicrobial activity. It is used as a disinfectant in periodontal therapy and surgical scrubs.[2]

Application

Chlorhexidine, the "gold standard" in oral antiseptics, has been used to optimize novel slow release chlorhexidine coatings based on fatty acids in surgical sutures[3]. Chlorhexidine, antibacterial agent, has been used in preparaing chlorhexidine-functionalized calcium phosphate nanoparticles, useful for oral hygiene and dental treatment[4].

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

hcodes

H318,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000483857
0000483857
1312398
1312398V
10318BJ

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Carolina Ferreira Franco et al.
Artificial organs, 27(5), 486-491 (2003-05-20)
The aim of this work was study the effect of the chlorhexidine : hydroxypropyl-beta-cyclodextrin (CLX : HP-beta-CD) inclusion compound (IC) on in vitro slabs of bovine dentine. The substantivity, antimicrobial activity, and morphological effect of this inclusion compound were evaluated.
Chlorhexidine-loaded calcium phosphate nanoparticles for dental maintenance treatment: combination of mineralising and antibacterial effects.
Kovtun A, et al.
Royal Society of Chemistry Advances, 2(3), 870-875 (2012)
Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review
Van Strydonck DA, et al.
Journal of Clinical Periodontology, 39, 1042-1055 (2012)
Matthias Maiwald et al.
PloS one, 7(9), e44277-e44277 (2012-09-18)
Skin antisepsis is a simple and effective measure to prevent infections. The efficacy of chlorhexidine is actively discussed in the literature on skin antisepsis. However, study outcomes due to chlorhexidine-alcohol combinations are often attributed to chlorhexidine alone. Thus, we sought
S Karki et al.
The Journal of hospital infection, 82(2), 71-84 (2012-08-15)
The topical use of chlorhexidine gluconate (CHG) is intended to reduce bacterial density on patients' skin. To assess the impact of body bath or skin cleansing with CHG-impregnated or CHG-saturated washcloths in preventing healthcare-associated infections and colonization. This systematic review
View All Related Papers

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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