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MilliporeSigma

284262

Sigma-Aldrich

Iodoacetic anhydride

Synonym(s):

2-Iodoacetic anhydride, 2-Iodoacetyl 2-iodoacetate, Iodoacetic acid anhydride, Iodoacetyl anhydride

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$94.00
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About This Item

Linear Formula:
(ICH2CO)2O
CAS Number:
54907-61-8
Molecular Weight:
353.88
Beilstein/REAXYS Number:
1812140
MDL number:
MFCD00001080
UNSPSC Code:
12352100
PubChem Substance ID:
24857144
NACRES:
NA.22

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form

solid

Quality Level

100

mp

47-49 °C (lit.)

solubility

chloroform: soluble 10%, clear to slightly hazy, yellow (pink or tan)

functional group

anhydride
ester
iodo

storage temp.

2-8°C

SMILES string

ICC(=O)OC(=O)CI

InChI

1S/C4H4I2O3/c5-1-3(7)9-4(8)2-6/h1-2H2

InChI key

RBNSZWOCWHGHMR-UHFFFAOYSA-N

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1 of 4

This Item
215163284688266477
Iodoacetic anhydride

Sigma-Aldrich

284262

Iodoacetic anhydride

Chloroacetic anhydride 95%

Sigma-Aldrich

215163

Chloroacetic anhydride

Decanoic anhydride 96%

Sigma-Aldrich

284688

Decanoic anhydride

Methyl 4-(hydroxymethyl)benzoate 98%

Sigma-Aldrich

266477

Methyl 4-(hydroxymethyl)benzoate

solubility

chloroform: soluble 10%, clear to slightly hazy, yellow (pink or tan)

solubility

chloroform: soluble 100 mg/mL, clear, colorless to faintly yellow

solubility

chloroform: soluble 100 mg/mL, clear, colorless to light yellow

solubility

chloroform: 25 mg/mL, clear, colorless to faint yellow or tan

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

form

solid

form

solid

form

solid

form

solid

mp

47-49 °C (lit.)

mp

48-60 °C (lit.)

mp

24-25 °C (lit.)

mp

47-50 °C (lit.)

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

functional group

anhydride

functional group

anhydride, chloro, ester

functional group

anhydride, ester

functional group

ester, hydroxyl

Application

Reagent used as linker for development of reagents used for differential protein quantitation via ion scanning

Reactant used for:
  • Sythesis of N-iodoacetyl glycosylamine derivatives and converting amino precursors to IA derivatives
  • Linking lysine residues to N-terminal α-amino groups of peptides
  • Capping amines and yielding a thiol reactive iodo-derivative
  • Iodoacetylation

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

hcodes

H301,H314

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN8891
MKCN7161
MKCH2071
MKCF3081
MKCC5307

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Rainer Hahn et al.
Journal of chromatography. A, 1217(40), 6203-6213 (2010-08-31)
To design a generic purification platform and to combine the advantages of fusion protein technology and matrix-assisted refolding, a peptide affinity medium was developed that binds inclusion body-derived N(pro) fusion proteins under chaotropic conditions. Proteins were expressed in Escherichia coli
M W Reed et al.
Bioconjugate chemistry, 6(1), 101-108 (1995-01-01)
An endogenous nuclear enzyme, RNase H, is an important component in determining the efficacy of antisense oligodeoxynucleotides (ODNs). In an effort to improve the potency of antisense ODNs, conjugates with three different nuclear targeting signal peptides were prepared. These short
S J Wood et al.
Bioconjugate chemistry, 3(5), 391-396 (1992-09-01)
We describe a new method for the transfer of carbohydrate moieties to polypeptides in which complex carbohydrate, in the form of glycosyl amino acid, is removed from an available glycoprotein, derivatized, and reacted with a polypeptide via an iodoacetylated alpha-amino
R Wetzel et al.
Bioconjugate chemistry, 1(2), 114-122 (1990-03-01)
A method is described for the highly selective modification of the alpha-amino groups at the N-termini of unprotected peptides to form stable, modified peptide intermediates which can be covalently coupled to other molecules or to a solid support. Acylation with
S J Wood et al.
International journal of peptide and protein research, 39(6), 533-539 (1992-06-01)
A novel method is described for the cyclization of peptides--or segments of polypeptides--which requires a free N-terminal alpha-amino group and a distal amino acid residue containing a nucleophilic side chain. The reaction is conducted in two steps, both in the

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