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286532

Sigma-Aldrich

3-Maleimidobenzoic acid N-hydroxysuccinimide ester

97%

Synonym(s):
MBS
Empirical Formula (Hill Notation):
C15H10N2O6
CAS Number:
Molecular Weight:
314.25
Beilstein/REAXYS Number:
1505254
MDL number:

assay

97%

mp

175-177 °C (lit.)

SMILES string

O=C1CCC(N1OC(C2=CC=CC(N3C(C=CC3=O)=O)=C2)=O)=O

InChI

1S/C15H10N2O6/c18-11-4-5-12(19)16(11)10-3-1-2-9(8-10)15(22)23-17-13(20)6-7-14(17)21/h1-5,8H,6-7H2

InChI key

LLXVXPPXELIDGQ-UHFFFAOYSA-N

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Application

Heterobifunctional crosslinking reagent reactive toward primary amine and sulfhydryl. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.0, followed by coupling to compounds containing sulfhydryl by thioether at same pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.

Other Notes

The aryl maleimide is less stable than alkyl maleimide linkers.

Certificate of Analysis

Certificate of Origin

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