292087

Sigma-Aldrich

1-Chloro-2-propanol

70%

Synonym(s):
Chloropropanol, Propylene chlorohydrin
Linear Formula:
CH3CH(OH)CH2Cl+CH3CHClCH2OH
CAS Number:
Molecular Weight:
94.54
Beilstein/REAXYS Number:
773653
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

70%

impurities

<25% 2-chloro-1-propanol

refractive index

n20/D 1.439 (lit.)

bp

126-127 °C (lit.)

density

1.111 g/mL at 25 °C (lit.)

SMILES string

CC(O)CCl

InChI

1S/C3H7ClO/c1-3(5)2-4/h3,5H,2H2,1H3

InChI key

YYTSGNJTASLUOY-UHFFFAOYSA-N

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General description

1-Chloro-2-propanol is formed as an intermediate during the degradation of meso-bis-(1-chloro-2-propyl)ether by Rhodococcus sp. strain DTB.

Application

1-Chloro-2-propanol has been used as:
  • chemical intermediate for the manufacture of propylene oxide, a starting material for production of polyurethane polyols and propylene glycol
  • as α,β-halohydrin standard during the enzymatic synthesis of α,β-halohydrins from gaseous alkenes

Packaging

25 g in glass bottle

Pictograms

FlameSkull and crossbones

Signal Word

Danger

hazcat

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 3

Flash Point(F)

125.6 °F - closed cup

Flash Point(C)

52 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Leif-Alexander Garbe et al.
FEMS microbiology ecology, 55(1), 113-121 (2006-01-20)
Rhodococcus sp. strain DTB (DSM 44534) was grown on a mixture of (R,R)-, (S,S)- and meso-bis-(1-chloro-2-propyl) ether (BCPE) as the sole source of carbon and energy. During BCPE degradation 1'-chloro-2'-propyl-3-chloro-2-prop-1-enyl-ether (DVE), 1-chloro-2-propanol and chloroacetone intermediates were formed. The BCPE or...
R W Biles et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 3(1), 27-33 (1983-01-01)
A 72:25 mixture of 1-chloro-2-propanol and 2-chloro-1-propanol was tested for genetic activity in a battery of short term tests. Chloropropanol was tested over a dose range of 527-167,250 micrograms/plate in the Salmonella/mammalian microsome mutagenicity assay. A dose dependent mutagenic response...
Reproductive toxicology. 1-Chloro-2-propanol.
Environmental health perspectives, 105 Suppl 1, 291-292 (1997-02-01)
J Geigert et al.
Applied and environmental microbiology, 45(2), 366-374 (1983-02-01)
The enzymatic synthesis of alpha,beta-halohydrins from gaseous alkenes is described. The enzymatic reaction required an alkene, a halide ion, dilute hydrogen peroxide, and a haloperoxidase enzyme. A wide range of gaseous alkenes were suitable for this reaction, including those containing...
Propylene chlorohydrins: toxicology, metabolism, and environmental fate.
R S Yang
Reviews of environmental contamination and toxicology, 99, 47-59 (1987-01-01)

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