299154

Sigma-Aldrich

L-Methionine-(methyl-13C,d3)

≥99 atom % 13C, ≥99 atom % D, ≥99% (CP)

Synonym(s):
SILAC Amino Acid
Linear Formula:
13CD3SCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
153.22
MDL number:
PubChem Substance ID:
NACRES:
NA.12
Pricing and availability is not currently available.

Quality Level

isotopic purity

≥99 atom % 13C
≥99 atom % D

assay

≥99% (CP)

optical activity

[α]25/D +23.1°, c = 1 in 1 M HCl

application(s)

protein expression: suitable

mp

284 °C (dec.) (lit.)

mass shift

M+4

SMILES string

[2H][13C]([2H])([2H])SCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1+1D3

InChI key

FFEARJCKVFRZRR-ZIHWZSJBSA-N

Related Categories

Application

Used in the methodology of stable isotope tagging of epitopes (SITE) for identification of virus-induced peptides in vaccine development.

Packaging

1 g in glass bottle
250 mg in glass bottle
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Martin Bachman et al.
Nature chemical biology, 11(8), 555-557 (2015-06-23)
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable...
Hugo D Meiring et al.
Molecular & cellular proteomics : MCP, 5(5), 902-913 (2006-01-25)
Identification of peptides presented in major histocompatibility complex (MHC) class I molecules after viral infection is of strategic importance for vaccine development. Until recently, mass spectrometric identification of virus-induced peptides was based on comparative analysis of peptide pools isolated from...
Valeria Spadotto et al.
Nucleic acids research, 48(1), 96-115 (2019-11-30)
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Microprocessor and its associated proteins. Through high resolution mass spectrometry (MS)- proteomics we discovered that this complex is extensively methylated, with 84...
Daniele Musiani et al.
Science signaling, 12(575) (2019-04-04)
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the involvement of PRMT5, the major type II PRMT, in cell survival and differentiation pathways that are important during development and in tumorigenesis. PRMT5...
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