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MilliporeSigma

308560

4-Amino-6-chloro-1,3-benzenedisulfonamide

98%

Synonym(s):

3-Chloroaniline-4,6-disulfonamide, 4-Amino-6-chlorobenzene-1,3-disulfonamide

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About This Item

Linear Formula:
H2NC6H2(Cl)(SO2NH2)2
CAS Number:
121-30-2
Molecular Weight:
285.73
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24858677
EC Number:
204-463-1
Beilstein/REAXYS Number:
1083877
MDL number:
MFCD00007933

Key Documents

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Product Name

4-Amino-6-chloro-1,3-benzenedisulfonamide, 98%

InChI key

IHJCXVZDYSXXFT-UHFFFAOYSA-N

InChI

1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)

SMILES string

Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O

assay

98%

form

powder

mp

257-261 °C (lit.)

functional group

chloro

Quality Level

100

Gene Information

human ... CA1(759), CA2(760), CA5A(763), CA5B(11238), CA9(768)

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This Item
665444122882C22415
4-Amino-6-chloro-1,3-benzenedisulfonamide 98%

Sigma-Aldrich

308560

4-Amino-6-chloro-1,3-benzenedisulfonamide

6-Amino-1,3-dipropyluracil 97%

Sigma-Aldrich

665444

6-Amino-1,3-dipropyluracil

2-Amino-4-chloro-6-methylpyrimidine 97%

Sigma-Aldrich

122882

2-Amino-4-chloro-6-methylpyrimidine

4-Chloroaniline 98%

Sigma-Aldrich

C22415

4-Chloroaniline

assay

98%

assay

97%

assay

97%

assay

98%

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

form

powder

form

solid

form

solid

form

chips, crystals or chunks

mp

257-261 °C (lit.)

mp

134-139 °C

mp

183-186 °C (lit.)

mp

67-70 °C (lit.)

functional group

chloro

functional group

-

functional group

chloro

functional group

-

Gene Information

human ... CA1(759), CA2(760), CA5A(763), CA5B(11238), CA9(768)

Gene Information

-

Gene Information

-

Gene Information

-

Application

4-Amino-6-chloro-1,3-benzenedisulfonamide was used in the synthesis of deuterated thiazides by undergoing condensation with appropriately labeled aldehydes[1].

General description

4-Amino-6-chloro-1,3-benzenedisulfonamide is a potent inhibitor of gastric pathogen, Helicobacter pylori (hpCA)[2].

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
STBL3789
STBK3661
STBJ6812
STBH0672
STBG2177V

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Mario Thevis et al.
Analytical chemistry, 74(15), 3802-3808 (2002-08-15)
The mass spectrometric behavior of 21 thiazide-based compounds after electrospray ionization in the negative ion mode and collision-induced dissociation was investigated on a triple-stage quadrupole mass spectrometer. The mass spectra show individual and common fragmentation patterns, the generations of which
M Yamazaki et al.
Chemical & pharmaceutical bulletin, 38(10), 2882-2883 (1990-10-01)
2-Amino-4-chloro-m-benzenedisulfonamide (ACBS) is a metabolite of hydrochlorothiazide. We reported that the ACBS concentration in erythrocytes was higher than in plasma in a patient. Therefore the binding of ACBS to rabbit erythrocyte was studied. The Scatchard plot showed the nonlinear plot
Biopharmaceutical studies of thiazide diuretics. III. In vivo formation of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide in a patient.
T Okuda et al.
Chemical & pharmaceutical bulletin, 35(8), 3516-3518 (1987-08-01)
B R Thomas et al.
Journal of chromatography. B, Biomedical applications, 657(2), 383-394 (1994-07-15)
A stability-indicating, quality control analysis method was developed and validated for the diuretic drug substances hydrochlorothiazide (HCTZ) and chlorothiazide (CTZ). Micellar electrokinetic capillary chromatography employing the anionic detergent sodium dodecyl sulfate at 30 mM in 20 mM sodium borate buffer
K Deventer et al.
Journal of chromatography. A, 1216(12), 2466-2473 (2009-02-04)
In sports, thiazide diuretics are used to flush out previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. Thiazide diuretics include compounds which are very unstable and hydrolyse in
View All Related Papers

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