Skip to Content
MilliporeSigma

325244

1,1,1,3,3,3-Hexafluoro-2-propanol

≥99.5%

Synonym(s):

HFP, Hexafluoroisopropanol

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
(CF3)2CHOH
CAS Number:
920-66-1
Molecular Weight:
168.04
EC Number:
213-059-4
UNSPSC Code:
12352104
PubChem Substance ID:
24859495
Beilstein/REAXYS Number:
1841007
MDL number:
MFCD00011651

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

BYEAHWXPCBROCE-UHFFFAOYSA-N

InChI

1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

SMILES string

OC(C(F)(F)F)C(F)(F)F

assay

≥99.5%

refractive index

n20/D 1.275 (lit.)

bp

59 °C (lit.)

mp

−4 °C (lit.)

density

1.596 g/mL at 25 °C (lit.)

Looking for similar products? Visit Product Comparison Guide

General description

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is an efficient hydrogen-bond donor and highly polar solvent for a reactions with Si-capped Π donors. HFIP is a solvent and its ability to induce self-assembly of an aromatic dipeptide was evaluated. HFIP-induced coacervation in aqueous mixed systems of catanionic surfactants of dodecyltrimethylammonium bromide (DTAB) and sodium dodecyl sulfate (SDS) was investigated.

Application

1,1,1,3,3,3-Hexafluoro-2-propanol (Hexafluoroisopropanol) was used as:
  • a crucial additive to improve the enantioselectivity of Friedel-Crafts alkylation of pyrrole with isatins
  • esterification reagent for the determination of aromatic acids in tissue by GLC and electron capture detection
  • additive which accelerates the Pictet-Spengler synthesis of tetrahydroisoquinolines in water catalyzed by a Bronsted acid-surfactant combined catalyst (BASC)

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

closed cup - boils before flash

flash_point_c

closed cup - boils before flash

ppe

Faceshields, Gloves, Goggles

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKBF9573V
STBB0159V
STBB0159
MKAA1626
07804TH

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Paul A Novick et al.
Journal of medicinal chemistry, 55(7), 3002-3010 (2012-03-17)
Drug design studies targeting one of the primary toxic agents in Alzheimer's disease, soluble oligomers of amyloid β-protein (Aβ), have been complicated by the rapid, heterogeneous aggregation of Aβ and the resulting difficulty to structurally characterize the peptide. To address
Tetrahedron Letters, 48, 835-835 (2007)
Chong Li et al.
Organic letters, 16(12), 3192-3195 (2014-06-10)
The highly enantioselective Friedel-Crafts alkylation of pyrrole with isatins catalyzed by the tridentate Schiff base/Cu catalyst was developed. Hexafluoroisopropanol (HFIP) was used as a crucial additive to improve the enantioselectivity. In the case of N-unprotected isatins, an innovative substrate slow-releasing
Lewis acid catalyst free electrophilic alkylation of silicon-capped pi donors in 1,1,1,3,3,3-hexafluoro-2-propanol.
Maxim O Ratnikov et al.
Angewandte Chemie (International ed. in English), 47(50), 9739-9742 (2008-11-05)
Amit U Joshi et al.
Nature neuroscience, 22(10), 1635-1648 (2019-09-26)
In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated neuroinflammation, thus increasing neuronal death. Here we show that the expression of neurotoxic proteins associated with these diseases in microglia alone is sufficient to directly trigger death of
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service