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Sigma-Aldrich

1-Cyclopentenecarboxylic acid

98%

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Linear Formula:
C5H7CO2H
CAS Number:
Molecular Weight:
112.13
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

98%

mp

121-124 °C (lit.)

SMILES string

OC(=O)C1=CCCC1

InChI

1S/C6H8O2/c7-6(8)5-3-1-2-4-5/h3H,1-2,4H2,(H,7,8)

InChI key

PYRZPBDTPRQYKG-UHFFFAOYSA-N

General description

1-Cyclopentenecarboxylic acid was evaluated as a new effective anticonvulsant during Anticonvulsant Screening Program (ASP) of Antiepileptic Drug Development Program.

Application

1-Cyclopentenecarboxylic acid was used in synthesis of cis-8-hexahydroindanecarboxylic acid via Diels-Alder reaction with butadiene. It was also used in synthesis of isoxazole derivatives.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Preparation of cis-Hexahydroindane-8-carboxylic Acid.
DAUBEN W, et al.
The Journal of Organic Chemistry, 26(2), 297-300 (1961)
Pengcheng P Shao et al.
Bioorganic & medicinal chemistry letters, 19(18), 5334-5338 (2009-08-18)
A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the benzylic position of benzamide were investigated to determine their effect on Na(v)1.7 inhibitory potency. The spirocyclobutyl substitution had the most significant enhancement
Marzanna Strupińska et al.
Acta poloniae pharmaceutica, 66(2), 155-159 (2009-09-02)
Previously obtained picolinic acid benzylamide is a potent anticonvulsant with low neurotoxicity. In search for new effective anticonvulsants twelve new benzylamides (1-12) were synthesized and preliminary evaluated in the Anticonvulsant Screening Program (ASP) of Antiepileptic Drug Development Program (ADDP) of

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