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329878

Sigma-Aldrich

Water-18O

(for PET), 97 atom % 18O

Synonym(s):
18O Water
Linear Formula:
H218O
CAS Number:
Molecular Weight:
20.02
MDL number:
PubChem Substance ID:
NACRES:
NA.12

Quality Level

description

Normalized with respect to hydrogen

isotopic purity

97 atom % 18O

form

liquid

technique(s)

PET imaging: suitable

bp

100 °C (lit.)

mp

0 °C (lit.)

density

1.11 g/mL at 20 °C (lit.)

compatibility

(for PET)

mass shift

M+2

SMILES string

[18OH2]

InChI

1S/H2O/h1H2/i1+2

InChI key

XLYOFNOQVPJJNP-NJFSPNSNSA-N

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General description

Water-18O is an isotopic analogue of water.

Application

Water-18O is an isotopically modified water, which is appropriate for PET applications.
It can also be used:
  • In paleoclimatology, hydrology, and plant ecology to determine soil stable oxygen isotope analysis of plant cellulose using δ18O.
  • To determine the diffusion of moisture into crystals using secondary ion mass spectrometry (SIMS).

Packaging

250 mg in serum bottle
1 g in serum bottle
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
Packaged in septum-sealed serum bottles.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Articles

Tools for Measuring Energy Expenditure

By first labeling molecular oxygen and then body water with 18O in a rat, Lifson measured the 18O abundance in expired CO2 and found the oxygens in CO2 exchanged with the oxygen in water. Indeed, these two oxygen containing species were in rapid isotopic equilibrium due to the actions of what we now know is carbonic anhydrase (Lifson, 1966)

Related Content

Stable Isotopes in PET (Positron Emission Tomography)

Labeled isotopes used as target materials in imaging have provided insights into the various mechanisms of human physiology and have lead to treatments for diseases. Water-18O is used for the production of 18F radionuclides, such as 18FDG (Fluoro-deoxyglucose). 18FDG used in PET and with other imaging technologies, such as CT/SPECT, has led to the diagnosis and treatment of a wide range of diseases, including lung, liver, and brain tumors, epilepsy, and Alzheimer’s.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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