329878

Sigma-Aldrich

Water-18O

(for PET), 97 atom % 18O

Synonym(s):
18O Water
Linear Formula:
H218O
CAS Number:
Molecular Weight:
20.02
MDL number:
PubChem Substance ID:
NACRES:
NA.12
Pricing and availability is not currently available.

Quality Level

description

Normalized with respect to hydrogen

isotopic purity

97 atom % 18O

application(s)

PET imaging: suitable

bp

100 °C (lit.)

mp

0 °C (lit.)

density

1.11 g/mL at 20 °C (lit.)

compatibility

(for PET)

mass shift

M+2

SMILES string

[18OH2]

InChI

1S/H2O/h1H2/i1+2

InChI key

XLYOFNOQVPJJNP-NJFSPNSNSA-N

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Application

Water-18O is an isotopically modified water, which is appropriate for PET applications.
It can also be used:
  • In paleoclimatology, hydrology, and plant ecology to determine soil stable oxygen isotope analysis of plant cellulose using δ18O.
  • To determine the diffusion of moisture into crystals using secondary ion mass spectrometry (SIMS).

Packaging

250 mg in serum bottle
1 g in serum bottle
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
Packaged in septum-sealed serum bottles.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Diffusion of Water Species in Yttria-Stabilized Zirconia
Duong T, et al.
Journal of the American Chemical Society, 92(11), 2731-2737 (2009)
Separating soil and leaf water 18O isotopic signals in plant stem cellulose
Sternberg, Leonel da Silveira Lobo and Anderson, William T and Morrison, Kanema
Geochimica et Cosmochimica Acta, 67(14), 2561-2566 (2003)
Xueyan Cao et al.
Food chemistry, 276, 266-273 (2018-11-10)
Milk glycoproteins are crucial nutrients with a variety of functions. However, whey N-glycoproteomes in human and bovine milks have not been characterized during lactation. Herein, using lectin enrichment and liquid chromatography tandem mass spectrometry, 68, 58, 100, and 98 N-glycoproteins...
Qingfei Zheng et al.
Nature communications, 11(1), 3241-3241 (2020-06-28)
Protein arginine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H3 and H4. While the precise epigenetic function of this modification has not been resolved, it has been shown to associate with general chromatin decompaction and compete...
Natalia A Cherepanova et al.
The Journal of cell biology, 218(8), 2782-2796 (2019-07-13)
Human cells express two oligosaccharyltransferase complexes (STT3A and STT3B) with partially overlapping functions. The STT3A complex interacts directly with the protein translocation channel to mediate cotranslational glycosylation, while the STT3B complex can catalyze posttranslocational glycosylation. We used a quantitative glycoproteomics...
Articles
By first labeling molecular oxygen and then body water with 18O in a rat, Lifson measured the 18O abundance in expired CO2 and found the oxygens in CO2 exchanged with the oxygen in water. Indeed, these two oxygen containing species were in rapid isotopic equilibrium due to the actions of what we now know is carbonic anhydrase (Lifson, 1966)
Read More
Related Content
Labeled isotopes used as target materials in imaging have provided insights into the various mechanisms of human physiology and have lead to treatments for diseases. Water-18O is used for the production of 18F radionuclides, such as 18FDG (Fluoro-deoxyglucose). 18FDG used in PET and with other imaging technologies, such as CT/SPECT, has led to the diagnosis and treatment of a wide range of diseases, including lung, liver, and brain tumors, epilepsy, and Alzheimer’s.
Read More

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