330264

Sigma-Aldrich

3,5-Dimethoxybenzyl chloride

99%

Synonym(s):
1-(Chloromethyl)-3,5-dimethoxybenzene
Linear Formula:
(CH3O)2C6H3CH2Cl
CAS Number:
Molecular Weight:
186.64
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

assay

99%

bp

115-118 °C/0.4 mmHg (lit.)

mp

46-48 °C (lit.)

SMILES string

COc1cc(CCl)cc(OC)c1

InChI

1S/C9H11ClO2/c1-11-8-3-7(6-10)4-9(5-8)12-2/h3-5H,6H2,1-2H3

InChI key

CCAWDIFJOBKBSE-UHFFFAOYSA-N

Related Categories

Application

3,5-Dimethoxybenzyl chloride was used in preparation of benzyl 7-(3,5-dimethoxyphenylacetoxy)octanoate, a precursor of curvularin. It was also used in the preparation of diethyl (3,5-dimethoxybenzyl) phosphonate via Wittig-Horner reaction.

Packaging

5 g in glass bottle

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 3261 8 / PGII

WGK Germany

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Guoliang Chen et al.
Chemical & pharmaceutical bulletin, 53(12), 1587-1590 (2005-12-06)
Seventeen novel resveratrol derivatives were synthesized. Their anti-inflammatory activities were tested on xylene-induced mouse ear edema. The pharmacological results showed that some compounds have potent anti-inflammatory activities.
Synthesis of (?)-dimethyl curvularin based on the palladium-catalyzed carbonylation of 3, 5-dimethoxybenzyl chloride using a butadiene telomer as a building block.
Takahashi T, et al.
Tetrahedron Letters, 21(40), 3885-3888 (1980)

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