331295

Sigma-Aldrich

Dichloroacetic anhydride

technical grade, 85%

Linear Formula:
(Cl2CHCO)2O
CAS Number:
Molecular Weight:
239.87
Beilstein/REAXYS Number:
512173
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

grade

technical grade

Quality Level

assay

85%

refractive index

n20/D 1.483 (lit.)

bp

214-216 °C (lit.)

density

1.574 g/mL at 25 °C (lit.)

SMILES string

ClC(Cl)C(=O)OC(=O)C(Cl)Cl

InChI

1S/C4H2Cl4O3/c5-1(6)3(9)11-4(10)2(7)8/h1-2H

InChI key

RQHMQURGSQBBJY-UHFFFAOYSA-N

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General description

Dichloroacetic anhydride is an acylating agent and was evaluated for inducing autoimmune responses.

Application

Dichloroacetic anhydride was employed as an acylating agent for acylation of 10-Deacetylbaccatin III using Pseudomonas cepacia. It was also used in the preparation of cellulose dichloroacetates.

Packaging

5 g in glass bottle

Pictograms

CorrosionSkull and crossbones

Signal Word

Danger

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2923 6.1(8) / PGIII

WGK Germany

WGK 3

Selective enzymatic acylation of 10-deacetylbaccatin III.
Lee D, et al.
Tetrahedron Letters, 39(49), 9039-9042 (1998)
A new soluble and hydrolytically cleavable intermediate in cellulose functionalization: cellulose dichloroacetate (CDCA).
Liebert T and Klemm D.
Acta Polym., 49(2-3), 124-128 (1998)
Ping Cai et al.
Toxicology and applied pharmacology, 216(2), 248-255 (2006-06-30)
Dichloroacetyl chloride (DCAC) is formed from trichloroethene (TCE), which is implicated in inducing/accelerating autoimmune response. Due to its potent acylating activity, DCAC may convert proteins to neo-antigens and thus could induce autoimmune responses. Dichloroacetic anhydride (DCAA), which is a similar...

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