332178

Sigma-Aldrich

DL-tert-Leucine

98%

Synonym(s):
(±)-2-Amino-3,3-dimethylbutyric acid, DL-α-tert-Butylglycine
Linear Formula:
(CH3)3CCH(NH2)COOH
CAS Number:
Molecular Weight:
131.17
Beilstein/REAXYS Number:
1721823
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

reaction suitability

reaction type: solution phase peptide synthesis

application(s)

peptide synthesis: suitable

mp

>300 °C (lit.)

SMILES string

CC(C)(C)C(N)C(O)=O

InChI

1S/C6H13NO2/c1-6(2,3)4(7)5(8)9/h4H,7H2,1-3H3,(H,8,9)

InChI key

NPDBDJFLKKQMCM-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Irina F Zhurko et al.
Molecules (Basel, Switzerland), 25(4) (2020-02-23)
Nitroxides are broadly used as molecular probes and labels in biophysics, structural biology, and biomedical research. Resistance of a nitroxide group bearing an unpaired electron to chemical reduction with low-molecular-weight antioxidants and enzymatic systems is of critical importance for these...
Fernando Formaggio et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 11(8), 2395-2404 (2005-01-26)
Terminally protected homopeptides of tert-leucine, from the dimer to the hexamer, co-oligopeptides of tert-leucine in combination with alpha-aminoisobutyric acid or glycine residues up to the hexamer level, and simple dipeptides representing known scaffolds for catalysts in asymmetric organic reactions were...
Philippe Bisel et al.
Organic & biomolecular chemistry, 6(15), 2655-2665 (2008-07-18)
The unique reactivity pattern elicited by the crowded tert-butyl group is highlighted by summarising characteristic applications. Starting from the use of this simple hydrocarbon moiety in chemical transformations, via its relevance in Nature and its implication in biosynthetic and biodegradation...
V W Cornish et al.
Biochemistry, 33(40), 12022-12031 (1994-10-11)
In order to gain greater insight into the effects of beta-branched amino acids on protein alpha-helices, hydrophobic amino acids with varying degrees of beta-branching, including the fully beta-substituted L-2-amino-3,3-dimethylbutanoic acid (ADBA), were incorporated into the protein T4 lysozyme. The unnatural...
Shu-Lai Liu et al.
Bioprocess and biosystems engineering, 28(5), 285-289 (2005-10-26)
Penicillin G acylase (PGA) from Kluyvera citrophila immobilized on Amberzyml was used for enantioselective hydrolysis of N-phenylacetylated-DL-tert-leucine (N-Phac-DL-Tle) to produce L-tert-leucine (L-Tle). The effects of various organic cosolvents on hydrolysis of N-Phac-DL-Tle have been investigated in aqueous-cosolvent medium. It was...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.