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332593

(2-Hydroxypropyl)-β-cyclodextrin

average Mw ~1,380

Synonym(s):

(2-Hydroxypropyl)-beta-cyclodextrin

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5 g

Available to ship TODAYfromMILWAUKEE

$74.00
25 g

Available to ship TODAYfromMILWAUKEE

$178.00
100 g

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$395.00
1 kg
Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
$872.00

About This Item

CAS Number:
PubChem Substance ID:
UNSPSC Code:
12352302
NACRES:
NA.22
EC Number:
420-920-1
Form:
powder

$74.00


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form

powder

Quality Segment

optical activity

[α]26/D +139°, c = 1 in H2O

mol wt

average Mw ~1,380

extent of labeling

0.6 molar substitution

mp

278 °C (dec.)

solubility

water: 180 g/L

SMILES string

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

General description

(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD) is a beta-cyclodextrin and hydroxyalkyl derivative and is widely used as a chiral solvent, phase transfer catalyst, and host molecule in organic synthesis. HP-β-CD can form inclusion complexes with guest molecules, which can help enhance the solubility, stability, and bioavailability of the guest molecule. It is an alternative to α-, β- and γ-cyclodextrin and exhibits a higher water solubility. HP-β-CD is commonly used as a drug solubilizer.

Application

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
HP-β-CD can be used:
  • As an additive in the separation of amino acids and lactic acids based on the coordination interactions between Cu2+ ions and analytes.
  • As a chiral selector in capillary electrophoresis, enabling the robust separation of diastereomeric derivatives of aspartic acid for analysis.
  • As a reagent to improve water solubility and anti-proliferative activity of pyrazolo[3,4-d] pyrimidines.
  • As formulation vehicle. It increases water solubility of the drug for successful delivery of medical agents to a biological system.
  • To increase the solubility of ropivacaine (RVC) upon complexation, which in turn enhances the pharmacological activity of RVC.
  • To increase the aqueous solubility of naproxen (NAP) in presence of polyvinylpyrrolidone (PVP).
  • As a template in the synthesis of hollow spherical copper sulfide nanoparticle assemblies.

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Show Differences

1 of 1

This Item
389145H107C0926
solubility

water: 180 g/L

solubility

-

solubility

H2O: soluble

solubility

-

Quality Level

200

Quality Level

100

Quality Level

300

Quality Level

300

form

powder

form

powder

form

powder

form

powder

mp

278 °C (dec.)

mp

-

mp

-

mp

-

extent of labeling

0.6 molar substitution

extent of labeling

1.0 molar substitution dextrin

extent of labeling

-

extent of labeling

4-10 (determined by NMR)

optical activity

[α]26/D +139°, c = 1 in H2O

optical activity

[α]23/D +125°, c = 1 in H2O

optical activity

-

optical activity

-


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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

>752.0 °F

flash_point_c

> 400 °C

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. is this product kosher certified or Vegan and without Vine or Grape ?

    1 answer
    1. This product is not kosher certified. This product is manufactured synthetically.

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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