337358

Sigma-Aldrich

4-Iodo-2-methylphenol

97%

Synonym(s):
4-Iodo-o-cresol
Linear Formula:
IC6H3(CH3)OH
CAS Number:
Molecular Weight:
234.03
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

97%

bp

105-110 °C/2 mmHg (lit.)

mp

67-68 °C (lit.)

SMILES string

Cc1cc(I)ccc1O

InChI

1S/C7H7IO/c1-5-4-6(8)2-3-7(5)9/h2-4,9H,1H3

InChI key

WSBDSSKIWDFOBQ-UHFFFAOYSA-N

Related Categories

General description

4-Iodo-2-methylphenol was prepared by direct iodination of 2-methylphenol in aqueous alcohol solvents by the action of a reagent prepared in situ from sodium hypochlorite and sodium iodide.

Application

4-Iodo-2-methylphenol was used as starting reagent in the synthesis of an agonist for the peroxisome proliferator-activated receptor δ (PPARδ) GW501516, a potential antiobesity drug.

Packaging

10 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

A highly efficient synthesis of antiobestic ligand GW501516 for the peroxisome proliferator-activated receptor d through in situ protection of the phenol group by reaction with a Grignard reagent.
Ham J and Kang H.
Tetrahedron Letters, 46(39), 6683-6686 (2005)
An efficient and selective method for the preparation of iodophenols.
Edgar KJ and Falling SN.
The Journal of Organic Chemistry, 55(18), 5287-5291 (1990)

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