(−)-1-(9-Fluorenyl)ethyl chloroformate solution

18 mM in acetone, for chiral derivatization

Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level


for chiral derivatization


18 mM in acetone


0.79 g/mL at 25 °C

storage temp.


SMILES string




InChI key


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General description

(-)-1-(9-Fluorenyl)ethyl chloroformate is mostly used as an in-capillary derivatization agent for the separation of amino acid (AA) derivatives by micellar electrokinetic chromatography (MEKC).


1 mL in glass bottle


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Signal Word


Hazard Statements

Target Organs

Central nervous system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN1090 - class 3 - PG 2 - Acetone, solution

WGK Germany


Flash Point(F)

-2.2 °F - closed cup - Not applicable

Flash Point(C)

-19 °C - closed cup - Not applicable

Certificate of Analysis
Certificate of Origin
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1513, 1-17 (2017-08-02)
Over the last 30years, (±)-1-(9-fluorenyl)ethyl chloroformate ((±)-FLEC) was used as a chiral derivatizing agent in various analytical applications involving a wide range of endogenous, pharmaceutical and environmentally relevant molecules. This comprehensive review aims to present all the significant aspects related...
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1467, 400-408 (2016-08-25)
In the context of bioanalytical method development, process automatization is nowadays a necessity in order to save time, improve method reliability and reduce costs. For the first time, a fully automatized micellar electrokinetic chromatography-mass spectrometry (MEKC-MS) method with in-capillary derivatization...
In-capillary derivatization with (-)-1-(9-fluorenyl) ethyl chloroformate as chiral labeling agent for the electrophoretic separation of amino acids.
Fradi I, et al.
Journal of Chromatography A, 1323, 338-347 (2014)
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1564, 199-206 (2018-06-19)
A targeted CE-MS approach was developed for the chiral analysis of biologically relevant amino acids in artificial cerebrospinal fluid (aCSF). In order to achieve chiral resolution, the five amino acids (Ser, Asn, Asp, Gln and Glu) were derivatized with (+)-1-(9-fluorenyl)ethyl...
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1590, 80-87 (2019-01-15)
D-amino acids (AA) analysis is becoming more and more relevant for metabolomics, therefore new analytical tools need to be developed. A common approach to achieve AA enantioseparation is chiral derivatization. Among the chiral derivatization reagents, (+) or (-)-1-(9-fluorenyl) ethyl chloroformate...

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