341274

Sigma-Aldrich

2-Methyl-2-vinyloxirane

95%

Synonym(s):
Isoprene monoxide
Empirical Formula (Hill Notation):
C5H8O
CAS Number:
Molecular Weight:
84.12
MDL number:
PubChem Substance ID:
NACRES:
NA.23
Pricing and availability is not currently available.

Quality Level

assay

95%

refractive index

n20/D 1.416 (lit.)

bp

80-81 °C (lit.)

density

0.857 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CC1(CO1)C=C

InChI

1S/C5H8O/c1-3-5(2)4-6-5/h3H,1,4H2,2H3

InChI key

FVCDMHWSPLRYAB-UHFFFAOYSA-N

Related Categories

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

F,Xi

Risk Statement

11-36/37/38

Safety Statement

16-26-36/37/39

RIDADR

UN 1993BF 3 / PGII

WGK Germany

WGK 3

Flash Point(F)

17.6 °F - closed cup

Flash Point(C)

-8 °C - closed cup

J J Bogaards et al.
Chemico-biological interactions, 102(3), 169-182 (1996-12-20)
The metabolism of isoprene was investigated with microsomes derived from cell lines expressing human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4. The formation of epoxide metabolites was determined by gas chromatographic analysis. CYP2E1 showed the highest rates of...
J J Bogaards et al.
Chemico-biological interactions, 117(1), 1-14 (1999-04-06)
In the present study, the enzymatic conjugation of the isoprene monoepoxides 3,4 epoxy-3-methyl-1-butene (EPOX-I) and 3,4-epoxy-2-methyl-1-butene (EPOX-II) with glutathione was investigated, using purified glutathione S-transferases (GSTs) of the alpha, mu, pi and theta-class of rat and man. HPLC analysis of...
Roberto Fabiani et al.
Mutation research, 629(1), 7-13 (2007-02-24)
Isoprene is produced in combustion processes and is widely used as an industrial chemical. It is a natural product emitted by plants and endogenously produced by humans and other mammals. Therefore, exposure to isoprene from both endogenous and exogenous sources...
J J Bogaards et al.
Chemico-biological interactions, 138(3), 247-265 (2001-11-21)
The present study was designed to explain the differences in isoprene toxicity between mouse and rat based on the liver concentrations of the assumed toxic metabolite isoprene diepoxide. In addition, extrapolation to the human situation was attempted. For this purpose...

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