341894

Sigma-Aldrich

Cyanogen bromide solution

3.0 M in methylene chloride

Linear Formula:
BrCN
CAS Number:
Molecular Weight:
105.92
Beilstein/REAXYS Number:
1697296
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

concentration

3.0 M in methylene chloride

solubility

alcohol: freely soluble
diethyl ether: freely soluble
water: freely soluble

density

1.443 g/mL at 25 °C

SMILES string

BrC#N

InChI

1S/CBrN/c2-1-3

InChI key

ATDGTVJJHBUTRL-UHFFFAOYSA-N

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General description

Cyanogen bromide solution induces template-guided condensation of oligonucleotides only in the presence of N-substituted morpholines.Mechanism of the phosphomonoester group activation by cyanogen bromide in N-substituted morpholine buffers is investigated.

Application

Cyanogen bromide (CNBr) solution may be used in the cyanogen bromide method for covalent immobilization of trypsin onto poly(2-hydroxyethyl methacrylate)/ polystyrene composite microspheres. It may be used in the preparation of CNBr-activated diol-silica, useful as silica support in HPLC.

Packaging

100 mL in glass bottle

Signal Word

Danger

Target Organs

Central nervous system

Supp Hazards

EUH032

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

T+,N

Risk Statement

26/27/28-32-34-40-51/53

Safety Statement

26-28-36/37/39-45-61

RIDADR

UN 2922 6.1(8) / PGI

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Z A Shabarova et al.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 27(5-6), 555-566 (2001-09-07)
Cyanogen bromide has been found to induce the template-guided condensation of oligonucleotides only in the presence of N-substituted morpholines. Based on 31P, 1H and 13C NMR spectroscopy data, the mechanism of the phosphomonoester group activation by cyanogen bromide in N-substituted...
Luis A Jurado et al.
Journal of chromatography. A, 971(1-2), 95-104 (2002-09-28)
To obtain silica supports for high-performance affinity chromatography, a method of preparing CNBr-activated diol-silica under anhydrous conditions was developed. Activation of the silane-derived hydroxyls with cyanogen bromide and triethylamine was optimized and demonstrated to efficiently couple several amino ligands (tryptophan...
Covalent immobilization of trypsin onto poly (2-hydroxyethyl methacrylate)/polystyrene composite microspheres by cyanogen bromide method and its enzymatic activity.
Okubo M, et al.
Colloid and Polymer Science, 265(11), 957-964 (1987)
Stuart Kyle et al.
Biomaterials, 31(36), 9395-9405 (2010-10-12)
Synthetic nanostructures based on self-assembling systems that aim to mimic natural extracellular matrix are now being used as substrates in tissue engineering applications. Peptides are excellent starting materials for the self-assembly process as they can be readily synthesised both chemically...
Bart Vanelslander et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(7), 2412-2417 (2012-02-07)
The spatial organization of biofilms is strongly regulated by chemical cues released by settling organisms. However, the exact nature of these interactions and the repertoire of chemical cues and signals that micro-organisms produce and exude in response to the presence...

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