348295

4-Morpholinecarbonyl chloride

98%

• Empirical Formula (Hill Notation): C₅H₈ClNO₂
• CAS Number: 15159-40-7
• Molecular Weight: 149.58
• UNSPSC Code: 12352100
• NACRES: NA.22
• PubChem Substance ID: 24861562
• EC Number: 239-213-0
• Beilstein/REAXYS Number: 116257
• MDL number: MFCD00037053
• Assay: 98%
• Form: liquid

Properties

• Quality Level: 200
• assay: 98%
• form: liquid
• refractive index: n20/D 1.498 (lit.)
• bp: 137-138 °C/33 mmHg (lit.)
• density: 1.282 g/mL at 25 °C (lit.)
• functional group: chloro, ether
• SMILES string: ClC(=O)N1CCOCC1
• InChI: 1S/C5H8ClNO2/c6-5(8)7-1-3-9-4-2-7/h1-4H2
• InChI key: XMWFMEYDRNJSOO-UHFFFAOYSA-N

Description

General description

4-Morpholinecarbonyl chloride is a photographic intermediate. Rates of solvolysis of 4-morpholinecarbonyl chloride with N-alkyl group in aqueous binary solvents of acetone, ethanol, methanol, methanol-d, 2,2,2-trifluoroethanol, pure water and D₂O has been determined. Preparation of 4-morpholinecarbonyl chloride has been reported.

Application

4-Morpholinecarbonyl chloride may be used in the preparation of a versatile fluorogenic label for biomolecular imaging.[1] It may be used in the synthesis of:

• morpholine-4-carboxylic acid [4-(2,4-dimethylphenyl)thiazol-2-yl]amide[2]
• morpholine-4-carboxylic acid [4-(2,4,6-trimethylphenyl)thiazol-2-yl]amide[2]
• 2-isopropyl-6-methylpyrimidin-4-yl morpholine-4-carboxylate

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H315,H319,H351
• pcodes: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2
• supp_hazards: EUH014
• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: 235.4 °F - closed cup
• flash_point_c: 113 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter