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363502

Sigma-Aldrich

Poly[(R)-3-hydroxybutyric acid]

natural origin

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Synonym(s):
(R)-3-Hydroxybutyric acid polymerized, PHB
Linear Formula:
[COCH2CH(CH3)O]n
CAS Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.23

Quality Level

transition temp

Tm 172 °C (DSC)

SMILES string

CC(O)CC(O)=O

InChI

1S/C12H20O6/c1-8(14)6-11(15)18-10(3)7-12(16)17-9(2)4-5-13/h5,8-10,14H,4,6-7H2,1-3H3

InChI key

QLACRIKFZRFWRU-UHFFFAOYSA-N

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This Item
916358915092757896
Poly[(R)-3-hydroxybutyric acid] natural origin

363502

Poly[(R)-3-hydroxybutyric acid]

Poly(3-hydroxybutyric acid) average Mn 10,000

916358

Poly(3-hydroxybutyric acid)

Poly(3-hydroxybutyric acid) natural origin, average Mn ~500,000

915092

Poly(3-hydroxybutyric acid)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

General description

Biocompatible, biodegradable polymer.

Application

Poly[(R)-3-hydroxybutyric acid (PHB) is a biodegradable and biocompatible polymer produced by several bacterial species, owing to its low resorbability and tunable properties, it may find uses in a variety of applications such as tissue engineering, controlled release systems etc.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Molecular mass of poly [(R)-3-hydroxybutyric acid] produced in a recombinant Escherichia coli.
Kusaka S, et al.
Applied Microbiology and Biotechnology, 47(2), 140-143 (1997)
Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds.
Ricotti L, et al.
Biomedical Materials (Bristol, England), 7(3), 035010-035010 (2012)
Engineering of Saccharomyces cerevisiae for the production of poly-3-d-hydroxybutyrate from xylose.
Sandstrom A G, et al.
AMB Express, 5(1), 14-14 (2015)
Rui-Yan Wang et al.
PloS one, 8(3), e57943-e57943 (2013-03-14)
A couple of DNA ligation-independent cloning (LIC) methods have been reported to meet various requirements in metabolic engineering and synthetic biology. The principle of LIC is the assembly of multiple overlapping DNA fragments by single-stranded (ss) DNA overlaps annealing. Here
Daniel Pfeiffer et al.
Journal of bacteriology, 194(21), 5909-5921 (2012-08-28)
Poly(3-hydroxybutyrate) (PHB) granules are covered by a surface layer consisting of mainly phasins and other PHB granule-associated proteins (PGAPs). Phasins are small amphiphilic proteins that determine the number and size of accumulated PHB granules. Five phasin proteins (PhaP1 to PhaP5)

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