366633

Sigma-Aldrich

1-(Phenylsulfonyl)indole

98%

Synonym(s):
NSC 683530, NSC 237040, Benzenesulfonic acid indolide, 1-(Benzenesulfonyl)indole
Empirical Formula (Hill Notation):
C14H11NO2S
CAS Number:
Molecular Weight:
257.31
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

assay

98%

mp

78-80 °C (lit.)

SMILES string

O=S(=O)(c1ccccc1)n2ccc3ccccc23

InChI

1S/C14H11NO2S/c16-18(17,13-7-2-1-3-8-13)15-11-10-12-6-4-5-9-14(12)15/h1-11H

InChI key

VDWLCYCWLIKWBV-UHFFFAOYSA-N

Application

Reactant for preparation of:
  • Antiplasmodial agents
  • Antifungal agents
  • Anti HIV-1 agents
  • Agonists of the histamine H4 receptor
  • Antibacterial agents
  • Camalexin analogs
  • CDK inhibitors and cytotoxic agents
  • Histone Deacetylase inhibitors
1-(Phenylsulfonyl)indole may be used in the preparation of 2-acyl-1-(phenylsulfonyl)indoles. It may be used in the synthesis of starting reagent required for the synthesis of the potentially useful intermediate, 1-(phenylsulfonyl)indol-3-yl trifluoromethanesulfonate (triflate).

Packaging

5 g in glass bottle

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

A direct lithiation route to 2-acyl-1-(phenylsulfonyl) indoles.
Jiang J and Gribble GW.
Synthetic Communications, 32(13), 2035-2040 (2002)
Synthesis of 1-(phenylsulfonyl) indol-3-YL trifluoromethanesulfonate.
Conway SC and Gribble GW.
Heterocycles, 30(1), 627-633 (1990)

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