372951

Sigma-Aldrich

tert-Butyldimethylsilyl chloride solution

1.0 M in THF

Synonym(s):
TBDMSCl solution, tert-Butyldimethylsilyl chloride, tert-Butyldimethylchlorosilane, tert-Butylchlorodimethylsilane solution
Linear Formula:
(CH3)3CSi(CH3)2Cl
CAS Number:
Molecular Weight:
150.72
Beilstein/REAXYS Number:
505999
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

concentration

1.0 M in THF

density

0.87 g/mL at 20 °C (lit.)
0.879 g/mL at 25 °C

SMILES string

CC(C)(C)[Si](C)(C)Cl

InChI

1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3

InChI key

BCNZYOJHNLTNEZ-UHFFFAOYSA-N

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Signal Word

Danger

Supp Hazards

EUH019

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2924 8(3) / PGII

WGK Germany

WGK 2

Flash Point(F)

1.4 °F - closed cup

Flash Point(C)

-17 °C - closed cup

Akshanth R Polepally et al.
Journal of clinical pharmacology, 55(10), 1101-1108 (2015-04-24)
A classic 2-period crossover bioavailability study was conducted to evaluate the relative and absolute bioavailability of immediate-release (IR) and extended-release (XR) lamotrigine formulations under steady-state conditions in elderly patients with epilepsy. On treatment days, each subject's morning dose (IR or...
Hiroaki Wakimoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(11), 2898-2909 (2014-04-10)
Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity in IDH-mutant gliomas. We prospectively implanted tumor specimens from 20 consecutive IDH1-mutant glioma resections into mouse brains and...
Some observations on the t-butyldimethylchlorosilane derivatization reaction.
K Bricknell et al.
Biochemical medicine, 23(1), 119-121 (1980-02-01)
Grethe M Olsen et al.
Neurochemistry international, 88, 47-52 (2014-12-03)
Pyruvate carboxylation, the anaplerotic reaction in the brain, has been demonstrated in astrocytes but not neurons. Since anaplerosis cannot proceed without cataplerosis in a closed system such as the brain, there have to be mechanisms to degrade molecules such as...
P Huttenloch et al.
Environmental science & technology, 35(21), 4260-4264 (2001-11-23)
The efficacy of the surface modification of natural diatomite and zeolite material by chlorosilanes is demonstrated. Chlorosilanes used were trimethylchlorosilane (TMSCI), tert-butyldimethylchlorosilane (TBDMSCI), dimethyloctadecylchlorosilane (DMODSCI), and diphenyldichlorosilane (DPDSCI) possessing different headgroups and chemical properties. Silanol groups of the diatomite and...

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