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374008

2,2,2-Trifluoroethanethiol

95%

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1 g

Estimated to ship onJune 08, 2026fromMILWAUKEE

$94.90
10 g

Estimated to ship TODAYfromMILWAUKEE

$510.00

About This Item

Linear Formula:
CF3CH2SH
CAS Number:
1544-53-2
Molecular Weight:
116.11
NACRES:
NA.22
PubChem Substance ID:
24863272
UNSPSC Code:
12352100
MDL number:
MFCD00134386
Assay:
95%
Form:
liquid

$94.90

Estimated to ship onJune 08, 2026Details

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vapor pressure

7.85 psi ( 20 °C)

Quality Level

200

assay

95%

form

liquid

refractive index

n20/D 1.352 (lit.)

bp

34-35 °C (lit.)

density

1.305 g/mL at 25 °C (lit.)

functional group

fluoro, thiol

SMILES string

FC(F)(F)CS

InChI

1S/C2H3F3S/c3-2(4,5)1-6/h6H,1H2

InChI key

RYRLLAOLJVDVNN-UHFFFAOYSA-N

General description

2,2,2-Trifluoroethanethiol is a fluorinated thiol. The microwave spectrum of 2,2,2-trifluoroethanethiol, and its deuterated species, CF3CH2SD has been studied.[1] The gas phase acidity and basicity of 2,2,2-trifluoroethanethiol (TFET) has been investigated by Fourier transform ion cyclotron resonance spectroscopy. Reaction of 2,2,2-trifluoroethanethiol on Mo(110) surface was studied using temperature-programmed section, Auger electron and infrared spectroscopies.
2,2,2-Trifluoroethanethiol is basic in nature and forms charge transfer complexes with molecular iodine.

Application


  • Advancements in Peptide Synthesis: A novel synthesis of β-thiol phenylalanine showcases the use of 2,2,2-Trifluoroethanethiol in facilitating one-pot ligation-desulfurization chemistry. This technique is pivotal for developing new peptide-based pharmaceuticals, enhancing both the efficiency and versatility of peptide synthesis (Malins et al., 2015).

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This Item
380229I2399177180
2,2,2-Trifluoroethanethiol 95%

Sigma-Aldrich

374008

2,2,2-Trifluoroethanethiol

Iodomethyl methyl ether contains copper as stabilizer, 95%

Sigma-Aldrich

380229

Iodomethyl methyl ether

Imidazole ACS reagent, ≥99% (titration)

Sigma-Aldrich

I2399

Imidazole

Methoxyacetone 95%

Sigma-Aldrich

177180

Methoxyacetone

assay

95%

assay

95%

assay

≥99% (titration)

assay

95%

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

100

refractive index

n20/D 1.352 (lit.)

refractive index

n20/D 1.546 (lit.)

refractive index

-

refractive index

n20/D 1.397 (lit.)

form

liquid

form

liquid

form

-

form

liquid

density

1.305 g/mL at 25 °C (lit.)

density

2.03 g/mL at 25 °C (lit.)

density

-

density

0.957 g/mL at 25 °C (lit.)

bp

34-35 °C (lit.)

bp

39 °C/20 mmHg (lit.)

bp

256 °C (lit.)

bp

118 °C (lit.)

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

-11.2 °F - closed cup

flash_point_c

-24 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
1419299
07018LH
11929HH
18409TD
12303DS

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Intrinsic acidity and basicity of 2, 2, 2-trifluoroethanethiol. The first experimental and theoretical study.
Molina MT, et al.
The Journal of Organic Chemistry, 61(16), 5485-5491 (1996)
Intrinsic (gas-phase) basicities and stability of charge-transfer complexes in solution.
Bouab W, et al.
Journal of Physical Organic Chemistry, 10(5), 343-346 (1997)
Harald Møllendal
The journal of physical chemistry. A, 112(32), 7481-7487 (2008-07-22)
The microwave spectrum of 2,2,2-trifluoroethanethiol, CF3CH2SH, and of one deuterated species, CF3CH2SD, has been investigated in the 7-80 GHz spectral interval. The microwave spectra of the ground and three vibrationally excited states belonging to three different normal modes of one
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Global Trade Item Number

SKUGTIN
374008-10G04061837866203
374008-1G04061837866210

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