MilliporeSigma
All Photos(2)

383449

Sigma-Aldrich

3-Formylchromone

97%

Synonym(s):
4-Oxo-4H-1-benzopyran-3-carboxaldehyde
Empirical Formula (Hill Notation):
C10H6O3
CAS Number:
Molecular Weight:
174.15
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

assay

97%

form

solid

mp

151-153 °C (lit.)

SMILES string

O=CC1=COc2ccccc2C1=O

InChI

1S/C10H6O3/c11-5-7-6-13-9-4-2-1-3-8(9)10(7)12/h1-6H

InChI key

FSMYWBQIMDSGQP-UHFFFAOYSA-N

Gene Information

human ... PTPN1(5770)

General description

Electrospray ionization mass spectrometry (ESI-MS) of protonated 3-formylchromone (3-FC) shows loss of H2 as a major fragmentation route to yield a ketene cation, which on reaction with water forms a protonated carboxylic acid.[1] The invivo salubrious effects of 3-FC against nitrosodiethylamine (NDEA) mediated early hepatocellular carcinogenesis has been investigated.[2] Synthesis and characterization of 3-FC and its derivatives has been reported.[3]

Application

3-Formylchromone may be used in the following studies:
  • Preparation of library of novel (E)-3-(2-arylcarbonyl-3-(arylamino)allyl)-4H-chromen-4-ones, by three-component domino reactions with (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones and anilines under catalyst-free conditions.[4]
  • Facile and ecofriendly synthesis of new chromonyl chalcones.[5]
  • Synthesis of 3-(2-hydroxybenzoyl)quinolines and 7H-chromeno[3,2-c]quinolin-7-ones.[6]

Packaging

5 g in glass bottle

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service