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389145
(2-Hydroxypropyl)-β-cyclodextrin
average Mw ~1,540
Synonym(s):
(2-Hydroxypropyl)-beta-cyclodextrin
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Available to ship TODAYfromMILWAUKEE | $79.70 $59.77 |
25 g | Available to ship TODAYfromMILWAUKEE | $201.00 |
About This Item
CAS Number:
PubChem Substance ID:
UNSPSC Code:
12352201
NACRES:
NA.22
EC Number:
420-920-1
Form:
powder
$59.77
List Price$79.70Save 25%Web-Only Promotion
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form
powder
Quality Segment
optical activity
[α]23/D +125°, c = 1 in H2O
mol wt
average Mw ~1,540
extent of labeling
1.0 molar substitution dextrin
SMILES string
CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
InChI
1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
InChI key
ODLHGICHYURWBS-RYJYQAAZSA-N
General description
2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide and used as a pharmaceutical excipient to improve the stability and bioavailability of drugs.
(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, is mainly used as a formulation vehicle to increase the dissolution of drugs in water for the successful delivery of medicinal agents to biological systems. It is commonly utilized as a substitute for α-, β- and γ-cyclodextrins.
(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, is mainly used as a formulation vehicle to increase the dissolution of drugs in water for the successful delivery of medicinal agents to biological systems. It is commonly utilized as a substitute for α-, β- and γ-cyclodextrins.
Application
(2-Hydroxypropyl)-β-cyclodextrin may be used:
- As an analytical standard for the determination of the analyte in pharmaceutical formulations as well as nanoparticle formulations by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), respectively.
- To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase HPLC technique.
- As a mobile phase additive for the effective separation of β-carbolines by HPLC.
- In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.
- As a chiral selector to resolve pantothenic acid by capillary electrophoresis.
The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
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This Item | |||
|---|---|---|---|
| description average Mw ~1,540 | description powder | description powder, BioReagent, suitable for cell culture | description Wacker Chemie AG |
| Quality Level 100 | Quality Level 300 | Quality Level 300 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| optical activity [α]23/D +125°, c = 1 in H2O | optical activity - | optical activity - | optical activity - |
| extent of labeling 1.0 molar substitution dextrin | extent of labeling - | extent of labeling 4-10 (determined by NMR) | extent of labeling molar substitution per 0.60 |
| mol wt average Mw ~1,540 | mol wt estimated mol wt ~1396 Da | mol wt 1396 Da | mol wt - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
>752.0 °F
flash_point_c
> 400 °C
ppe
Eyeshields, Gloves, type N95 (US)
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How to know a shelf life of 2-Hydroxypropyl)-β-cyclodextrin? Your product COA does not provide any information about a date of expiration. I'd appreciate your help. Thanks.
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