average Mw ~1,540

CAS Number:
EC Number:
PubChem Substance ID:

Quality Level

optical activity

[α]23/D +125°, c = 1 in H2O

mol wt

average Mw ~1,540

extent of labeling

1.0 molar substitution dextrin

SMILES string




InChI key


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General description

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, is mainly used as a formulation vehicle to increase the dissolution of drugs in water for the successful delivery of medicinal agents to biological systems. It is commonly utilized as a substitute for α-, β- and γ-cyclodextrins.


(2-Hydroxypropyl)-β-cyclodextrin may be used:
  • As an analytical standard for the determination of the analyte in pharmaceutical formulations as well as nanoparticle formulations by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), respectively.
  • To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase HPLC technique.
  • As a mobile phase additive for the effective separation of β-carbolines by HPLC.
  • In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.
  • As a chiral selector to resolve pantothenic acid by capillary electrophoresis.

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.


5, 25 g in poly bottle


13 - Non Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Chromatographic Separation and Purification of Novel Drug Excipient 2-Hydroxypropyl-beta-Cyclodextrin [J]
Yimin Z, et al.
Chinese Journal of Analytical Chemistry, 5 (2006)
Direct chiral resolution of pantothenic acid using 2-hydroxypropyl-beta-cyclodextrin in capillary electrophoresis
Kodama S, et al.
Journal of Chromatography A, 811(1-2), 269-273 (1998)
M Agüeros et al.
Journal of pharmaceutical and biomedical analysis, 39(3-4), 495-502 (2005-06-11)
A rapid and simple HPLC method with evaporative scattering detection (ELSD) has been developed for the separation and quantitation of beta-cyclodextrin (beta-CD), 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) and poly(methyl vinyl ether-co-maleic anhydride) (Gantrez). Separation was carried out on a Zorbax Eclipse XDB-Phenyl narrow...
The role of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin in the secondary chemical equilibria associated to the separation of beta-carbolines by HPLC
Leon AG, et al.
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 57(1-4), 577-583 (2007)
S E Lucangioli et al.
Journal of chromatography. A, 871(1-2), 207-215 (2000-03-29)
In this work development, optimization and validation of a cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) method is proposed to resolve separation of the sertraline hydrochloride and synthesis-related substances. Sertraline hydrochloride, the cis-(1S,4S) enantiomer form, is used as an antidepressant therapeutic...

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