392243

Sigma-Aldrich

1-Formylpiperazine

technical grade, 85%

Synonym(s):
Piperazine-1-carboxaldehyde
Empirical Formula (Hill Notation):
C5H10N2O
CAS Number:
Molecular Weight:
114.15
Beilstein/REAXYS Number:
110295
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

grade

technical grade

Quality Level

assay

85%

density

1.107 g/mL at 25 °C (lit.)

SMILES string

HC(=O)N1CCNCC1

InChI

1S/C5H10N2O/c8-5-7-3-1-6-2-4-7/h5-6H,1-4H2

InChI key

MSSDTZLYNMFTKN-UHFFFAOYSA-N

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General description

1-Formylpiperazine, a secondary alicyclic amine is a piperazine derivative. Its synthesis has been reported. The kinetics of its reaction with O-aryl S-aryl dithiocarbonates has been studied. The IR and Raman spectra of 1-formylpiperazine have been investigated.

Application

1-Formylpiperazine is sutable for use as a test compound in the kinetic study of the reaction of 4-nitrophenyl 2-thiophenecarboxylate with secondary alicyclic amines.

Packaging

25 mL in glass bottle

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xn

Risk Statement

22-37/38-41

Safety Statement

26-36

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

215.6 °F - closed cup

Flash Point(C)

102 °C - closed cup

Kinetics and mechanism for the reaction of 4-nitrophenyl 2-thiophenecarboxylate with secondary alicyclic amines.
Um IH, et al.
Bull. Korean Chem. Soc., 23(3), 381-384 (2002)
Reactions of O-aryl S-aryl dithiocarbonates with secondary alicyclic amines in aqueous ethanol. Kinetics and mechanism.
Castro EA, et al.
Journal of Physical Organic Chemistry, 24(6), 466-473 (2011)
1-Formylpiperazine and related compounds.
Horrom BW, et al.
Journal of the American Chemical Society, 77(3), 753-754 (1955)
Gürkan Keşan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 118, 1113-1120 (2013-10-29)
Infrared and Raman spectra of 1-formylpiperazine (1-fp) have been recorded in the region of 4000-50 cm(-1). The conformational analysis, optimized geometric parameters, normal mode frequencies and corresponding vibrational assignments of 1-fp (C5H10N2O) have been examined by means of Becke-3-Lee-Yang-Parr (B3LYP)...
Gu-cai Li et al.
Die Pharmazie, 70(8), 511-514 (2015-09-19)
Five indolin-2-one derivatives bearing piperazinylbutyl side chains attached to the amide nitrogen were synthesized from 2-indolinone. 1-(4-Bromobutyl)-indolin-2-one was reacted with 1-piperazinecarboxaldehyde to form 1-(4-(4-formyl-1-piperazinyl)butyl)indolin-2-one (2). In the presence of H2SO4, the aldehyde moiety was removed from 1-(4-(4-formyl-1-piperazinyl)butyl)indolin-2-one and then 1-(4-(1-piperazinyl)butyl)indolin-2-one...

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