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395005

Supelco

N,N-Dimethylformamide di-tert-butyl acetal

for GC derivatization, LiChropur

Synonym(s):
1,1-Di-tert-butoxy-N,N-dimethylmethylamine, 1,1-Di-tert-butoxytrimethylamine
Linear Formula:
(CH3)2NCH[OC(CH3)3]2
CAS Number:
Molecular Weight:
203.32
Beilstein:
969629
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization

Quality Level

Assay

≥90.0%

form

liquid

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.413 (lit.)

bp

56-57 °C/8 mmHg (lit.)

density

0.848 g/mL at 25 °C (lit.)

SMILES string

CN(C)C(OC(C)(C)C)OC(C)(C)C

InChI

1S/C11H25NO2/c1-10(2,3)13-9(12(7)8)14-11(4,5)6/h9H,1-8H3

InChI key

DBNQIOANXZVWIP-UHFFFAOYSA-N

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This Item
40263394998394963
form

liquid

form

liquid

form

liquid

form

liquid

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

reaction suitability

-

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations, reagent type: derivatization reagent
reaction type: Esterifications

refractive index

n20/D 1.413 (lit.)

refractive index

n20/D 1.413 (lit.)

refractive index

n20/D 1.409 (lit.)

refractive index

n20/D 1.396 (lit.)

bp

56-57 °C/8 mmHg (lit.)

bp

56-57 °C/8 mmHg (lit.)

bp

67-68 °C/14 mmHg (lit.)

bp

102-103 °C/720 mmHg (lit.)

density

0.848 g/mL at 25 °C (lit.)

density

0.848 g/mL at 25 °C (lit.)

density

0.854 g/mL at 25 °C (lit.)

density

0.897 g/mL at 25 °C (lit.)

General description

N,N-Dimethylformamide di-tert-butyl acetal is an derivatizing reagent.

Application

It was used as derivatizing agent in a study to determine cocaine and benzoyl ecgonine in urine using GC with on-column alkylation.
Reagent used for the preparation of indolizines via intermolecular cyclization of picolinium salts.

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

95.0 °F - closed cup

Flash Point(C)

35 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Tetrahedron Letters, 47, 8817-8817 (2006)
N C Jain et al.
Journal of forensic sciences, 22(1), 7-16 (1977-01-01)
A gas chromatographic procedure has been developed for the simultaneous determination of cocaine and benzoyl ecgonine in urine specimens. The two drugs are extracted by isopropanol/chloroform from urine samples saturated with a bisalt buffer. The organic extract is evaporated to

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