397210

Sigma-Aldrich

2-Amino-5-chloro-2′-fluorobenzophenone

98%

Linear Formula:
H2NC6H3(Cl)C(O)C6H4F
CAS Number:
Molecular Weight:
249.67
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

assay

98%

mp

95-98 °C (lit.)

SMILES string

Nc1ccc(Cl)cc1C(=O)c2ccccc2F

InChI

1S/C13H9ClFNO/c14-8-5-6-12(16)10(7-8)13(17)9-3-1-2-4-11(9)15/h1-7H,16H2

InChI key

GTGMXPIQRQSORU-UHFFFAOYSA-N

Application

2-Amino-5-chloro-2′-fluorobenzophenone is suitable electrophilic coupling reagent for the determination of iron(III) in environmental waters, soils and industrial effluent samples. It may be used in the synthesis of following:
  • 2,4-disubstituted quinolones, via Meyer-Schuster rearrangement
  • 6-chloro-2-methyl-4-(2-fluorophenyl) quinazoline
  • N-desalkylflurazepam
  • benzotriazepines
  • diazepam-related benzodiazepines.

Packaging

25 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Journal of the American Chemical Society, 112, 3969-3969 (1990)
Ionic liquid-an efficient recycalable system for the synthesis of 2, 4-disubstituted quinolines via Meyer-Schuster rearrangement.
Saqrma R and Prajapati D.
Synlett, 19, 3001-3005 (2008)
J. Chem. Res. Synop., 2-2 (1991)
Bhawana Sati et al.
Acta pharmaceutica (Zagreb, Croatia), 63(3), 385-396 (2013-10-25)
During the manufacture of bulk drug midazolam various impurities arised that can be the related products or degradation products. Structures of eight impurities that can arise during the manufacture of bulk drug midazolam were proposed. In the present work, synthesis...

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