408719

Polyethylenimine, branched

average M_w ~800 by LS, average M_n ~600 by GPC

• Synonym(s): PEI, ethylenediamine branched
• Linear Formula: H(NHCH₂CH₂)_nNH₂
• CAS Number: 25987-06-8
• MDL number: MFCD00084427
• NACRES: NA.23

Properties

• form: viscous liquid
• Quality Level: 200
• mol wt: average M_n ~600 by GPC; average M_w ~800 by LS
• refractive index: n20/D 1.5240
• density: 1.050 g/mL at 25 °C
• InChI: 1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2
• InChI key: SFLOAOINZSFFAE-UHFFFAOYSA-N

Description

General description

Polyethyleneimine is a hydrophilic polymerwidely used as a non-viral synthetic vector for invivo delivery of therapeutic nucleic acids. Owing to its excellentphysicochemical properties, it is applied in many fields like the separationand purification of proteins, carbon dioxide absorption, drug carriers,effluent treatment, and biological labels.

Application

Branched PEI can be used as a precursor to synthesize conjugated polyplexes for efficient gene transfection. Conjugation of PEI with Jeffamine polyether and guanidinylation of the amino groups of PEI reduce the cytotoxicity of the polyplexes and protect them from aggregation in the presence of serum proteins.

Bamboo charcoal impregnated with PEI can be used as a CO₂ adsorbent. Numerous amino groups present in PEI can react with CO₂ due to acid-alkali interaction and enhance the adsorption capacity of bamboo charcoal.

It can also be used to prepare cross-linked water-soluble polymers with high coordination capabilities towards organic drug molecules.

Features and Benefits

• Branched PEI has better complexation and buffering capacity.
• High ion exchange capacity and affinity toward proteins.
• SignificantDNA transfer efficiency.

Physical form

Branched polymer

Safety Information

• Pictograms: GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H302 - H318 - H411
• Precautionary Statements: P264 - P270 - P273 - P280 - P301 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 356.0 °F
• Flash Point(C): 180 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves