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408727

Sigma-Aldrich

Polyethylenimine, branched

average Mw ~25,000 by LS, average Mn ~10,000 by GPC, branched

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Synonym(s):
aziridine, homopolymer, PEI
Linear Formula:
H(NHCH2CH2)nNH2
CAS Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.23

Quality Level

form

viscous liquid

mol wt

average Mn ~10,000 by GPC
average Mw ~25,000 by LS

impurities

≤1% water

refractive index

n20/D 1.5290

viscosity

13,000-18,000(50 °C)

bp

250 °C (lit.)

density

1.030 g/mL at 25 °C

SMILES string

C1CN1

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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1 of 4

This Item
408719764604765090
refractive index

n20/D 1.5290

refractive index

n20/D 1.5240

refractive index

-

refractive index

-

viscosity

13,000-18,000(50 °C)

viscosity

-

viscosity

-

viscosity

-

density

1.030 g/mL at 25 °C

density

1.050 g/mL at 25 °C

density

-

density

-

mol wt

average Mn ~10,000 by GPC

mol wt

average Mn ~600 by GPC, average Mw ~800 by LS

mol wt

average Mn 2100

mol wt

average Mn 10,000

impurities

≤1% water

impurities

-

impurities

-

impurities

-

General description

Polyethylenimine (PEI) is a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent. Branched PEI can be synthesized by cationic ring-opening polymerization of aziridine. PEI-based particles can also be used as adjuvants for vaccines. Owing to its excellent physicochemical properties, it is applied in many fields like the separation and purification of proteins, carbon dioxide absorption, drug carriers, effluent treatment, and biological labels.

Application

Polyethyleneimine can be used as a non-viral synthetic polymer vector for in vivo delivery of therapeutic nucleic acids. The interaction between negatively charged nucleic acids and positively charged polymer backbone results in the formation of nano-sized complexes. This neutralized complex protects the enclosed nucleic acid from enzymes and maintains its stability till the cellular uptake takes place. For example, human serum albumin conjugated PEI shows good pDNA transfection and low toxicity.

PEI can be used to functionalize single-walled nanotubes (SWNTs) to improve their solubility and biocompatibility while maintaining the structural integrity of the original SWNT. Covalently functionalized SWNTs find application in CO2 absorption and gene delivery.

Branched PEI can also be used to modify the surface properties of adsorbents. PEI-modified hydrous zirconium oxide/PAN nanofibers are used for the defluorination of groundwater as they show high fluoride adsorption capacity and a wide working pH range.

Features and Benefits

Primary and secondary amine groups of PEI can efficiently bind to drugs, nucleic acids, and other functional moieties.

Branched PEI has better complexation andbuffering capacity.

Physical form

Branched polymer

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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