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414174

Sigma-Aldrich

5-Formyluracil

98%

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Empirical Formula (Hill Notation):
C5H4N2O3
CAS Number:
Molecular Weight:
140.10
MDL number:
PubChem Substance ID:
NACRES:
NA.22

assay

98%

form

powder

mp

>300 °C (dec.) (lit.)

SMILES string

O=CC1=CNC(=O)NC1=O

InChI

1S/C5H4N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1-2H,(H2,6,7,9,10)

InChI key

OHAMXGZMZZWRCA-UHFFFAOYSA-N

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1 of 4

This Item
272310447706B83207
vibrant-m

414174

5-Formyluracil

vibrant-m

272310

5-Methylquinoxaline

vibrant-m

447706

5-Chlorosalicylaldehyde

vibrant-m

B83207

5-Bromovaleronitrile

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

mp

>300 °C (dec.) (lit.)

mp

20-21 °C (lit.)

mp

100-102 °C (lit.)

mp

-

form

powder

form

-

form

solid

form

liquid

Application

5-Formyluracil may be used for the preparation of covalently linked base with 5-aminocytosine pair via Schiff base formation.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Katsuhito Kino et al.
Biochemistry, 43(10), 2682-2687 (2004-03-10)
5-Formyluracil (fU) is a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation. Although this residue is a potentially mutagenic lesion and is removed by several base excision repair enzymes, it is unknown whether fU is the substrate
Fernanda M Prado et al.
Free radical biology & medicine, 47(4), 401-409 (2009-05-12)
The decomposition of organic hydroperoxides into peroxyl radicals is a potential source of singlet molecular oxygen [O2 (1Deltag)] in biological systems. This study shows that 5-(hydroperoxymethyl)uracil (5-HPMU), a thymine hydroperoxide within DNA, reacts with metal ions or HOCl, generating O2
E J Privat et al.
Mutation research, 354(2), 151-156 (1996-07-22)
5-Formyluracil is a mutagenic base formed in DNA by oxidation of the thymine methyl group. Whereas the thymine methyl group is electron donating, the formyl group is electron withdrawing, predicting increased ionization of the N-3 imino proton under physiological conditions.
Monica Baldini et al.
Inorganic chemistry, 42(6), 2049-2055 (2003-03-18)
Two new 5-formyluracil thiosemicarbazone (H(3)ut) derivatives, Me-H(3)ut (1) and Me(2)-H(3)ut (2), were synthesized by reacting thiosemicarbazides, mono- and dimethylated on the aminic nitrogen, with 5-formyluracil and were subsequently characterized. These ligands, treated with copper chloride and nitrate, afforded three complexes:
Chikara Dohno et al.
Journal of the American Chemical Society, 127(47), 16681-16684 (2005-11-25)
We here present a novel covalently linked base pair via Schiff base formation between 5-formyluracil (fU) and 5-aminocytosine (AmC). Formation of the Schiff base linkage proceeds reversibly and does not require any additives. The cross-linked DNA is very stable under

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