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42085

Sigma-Aldrich

1-Fluoro-2,4-dinitrobenzene

purum p.a., ≥98.0% (GC)

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Synonym(s):
2,4-Dinitro-1-fluorobenzene, DNFB, DNPF, FDNB, Sanger reagent
Linear Formula:
(O2N)2C6H3F
CAS Number:
Molecular Weight:
186.10
Beilstein/REAXYS Number:
398632
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

grade

purum p.a.

assay

≥98.0% (GC)

form

liquid

refractive index

n20/D 1.569 (lit.)

bp

178 °C/25 mmHg (lit.)

mp

25-27 °C (lit.)

density

1.482 g/mL at 25 °C (lit.)

cation traces

Ca: ≤50 mg/kg
Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤50 mg/kg
K: ≤100 mg/kg
Na: ≤100 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(F)c(c1)[N+]([O-])=O

InChI

1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H

InChI key

LOTKRQAVGJMPNV-UHFFFAOYSA-N

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1 of 4

This Item
D1529F7250237329
vibrant-m

42085

1-Fluoro-2,4-dinitrobenzene

vibrant-m

D1529

1-Fluoro-2,4-dinitrobenzene

vibrant-m

F7250

Fluorescein isothiocyanate isomer I

vibrant-m

237329

1-Chloro-2,4-dinitrobenzene

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

density

1.482 g/mL at 25 °C (lit.)

density

1.482 g/mL at 25 °C (lit.)

density

-

density

-

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

refractive index

n20/D 1.569 (lit.)

refractive index

n20/D 1.569 (lit.)

refractive index

-

refractive index

-

form

liquid

form

solid

form

powder

form

solid

General description

1-Fluoro-2,4-dinitrobenzene(FDNB, Sanger′s reagent) is used to identify the amino acid sequence. Thischemical is used to label the free amino groups in proteins and peptides. Itcan also be used to protect the amine group, and for phenol deoxygenation. Additionally,it is a very helpful reagent for nucleophilic substitution reactions tointroduce a chromophore group to amines, phenols, and thiols.

Application

1-Fluoro-2,4-dinitrobenzene is used as a derivatization agent:
  • For aminoglycoside compounds such as amikacine, tobramycine, gentamycine, sisomycine, neamine, neomycine-B and neomycine-C.
1-Fluoro-2,4-dinitrobenzene can also be used:
  • To examine the kinetic analysis and analytical uses of reaction with thiols in the presence of several surfactants.

pictograms

Exclamation markHealth hazard

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

327.2 °F

flash_point_c

164 °C

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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