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430471

Poly(D,L-lactide-co-glycolide)

ester terminated, Mw 50,000-75,000

Synonym(s):

Lactel® B6006-1, PLGA

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Size/SKUAvailabilityPrice
1 g

Available to ship TODAYfromMILWAUKEE

$89.50
5 g

Available to ship TODAYfromMILWAUKEE

$302.00

About This Item

Linear Formula:
[C3H4O2]x[C2H2O2]y
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
MDL number:

$89.50


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Quality Segment

form

amorphous

feed ratio

lactide:glycolide 85:15

mol wt

Mw 50,000-75,000

degradation timeframe

<6 months

viscosity

0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)

transition temp

Tg 45-50 °C

solubility

ethyl acetate, chloroform, acetone and THF: soluble

storage temp.

2-8°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

InChI

1S/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)

InChI key

XBBVURRQGJPTHH-UHFFFAOYSA-N

General description

Characteristic properties of ester terminated poly(D,L-lactide-co-glycolide) (PLGA) are in vivo biodegradability, tunable drug release profile and very high encapsulation capacity.

Application

PLGA polymers find uses in the production of biodegradable medical sutures and for controlled drug release. PLGA microspheres have been reported for use in controlled release of human growth hormone. Thin membranes of blended polymers constituting of PLGA/polycaprolactone/β-tricalcium phosphate have been used in guided bone regeneration.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Lactel is a registered trademark of Evonik Corp

Compare Similar Items

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Show Differences

1 of 1

This Item
802182P2066P1941
description

ester terminated, Mw 50,000-75,000

description

lactide:glycolide (50:50), ester terminated, average Mw 100,000

description

lactide:glycolide 65:35, Mw 40,000-75,000

description

lactide:glycolide (75:25), mol wt 66,000-107,000

form

amorphous

form

solid

form

pellets

form

pellets

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

ethyl acetate, chloroform, acetone and THF: soluble

solubility

-

solubility

-

solubility

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

feed ratio

lactide:glycolide 85:15

feed ratio

lactide:glycolide (50:50)

feed ratio

lactide:glycolide 65:35

feed ratio

lactide:glycolide (75:25)

viscosity

0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)

viscosity

-

viscosity

-

viscosity

-


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–8 of 8 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How is this Product No. 430471 synthesized (Poly(DL-lactide-co-glycolide)?

    1 answer
    1. To synthesize product 430471, 1-dodecanol is used as an initiator and stannous octoate is used as a catalyst to start the ring opening polymerization of D,L-lactide and glycolide monomers.

      Helpful?

  4. What are the end groups of Product No. 430471 (Poly(DL-lactide-co-glycolide)?

    1 answer
    1. Product 430471 has a dodecyl (12 carbon) ester on one end of the polymer chain and a hydroxyl end group on the other.

      Helpful?

  5. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  6. Is Product No. 403471 a resorbable polymer?

    1 answer
    1. Yes, Product No. 430471 has a resorption time of 5-6 months.

      Helpful?

  7. What is the density of Product No. 430471 Poly(DL-lactide-co-glycolide)?

    1 answer
    1. According to the manufacturer, product 430471 has a theoretical density of 1.27g/mL.

      Helpful?

  8. What is the tensile strength of Product No. 403471 Poly(DL-lactide-co-glycolide)?

    1 answer
    1. Product 430471 has a tensile strength of 6000 - 8000 psi, with an elongation of 3-10%.

      Helpful?

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