J Araújo et al.
International journal of pharmaceutics, 393(1-2), 167-175 (2010-04-07)
The purpose of this study was to develop a novel nanostructured lipid carrier (NLC) for the intravitreal-targeting delivery of triamcinolone acetonide (TA) by direct ocular instillation. A five-level central composite rotable design was used to study the influence of four...
Tarek A Ahmed et al.
Pharmaceutical development and technology, 16(5), 497-510 (2010-06-17)
A suitable topical formulation of mefenamic acid was developed in order to eliminate the gastrointestinal disorders associated with its oral administration. Drug coprecipitates prepared with different polymers at various drug-to-polymer ratios improved drug solubility and dissolution compared to pure drug...
Supramolecular assembly of cyclodextrin-based nanospheres for gene delivery.
Min-min Fan et al.
Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1, e141-e142 (2011-12-27)
Diego A Chiappetta et al.
Nanomedicine (London, England), 8(2), 223-237 (2012-11-24)
To investigate the intranasal administration of poly(ethylene oxide)-poly(propylene oxide) polymeric micelles loaded with high payloads of the first-line antiretroviral drug efavirenz for targeting to the CNS. The effect of micellar size and composition and drug payload was assessed, employing simple...
Anne Bee Hegge et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(1), 65-74 (2012-05-23)
Solubilization and stabilization from rapid degradation by the use of nanocarriers are necessary to exploit curcumin's phototoxic potential towards pathogenic bacteria. However, maintenance of the phototoxicity requires a careful selection of type and amount of nanocarrier. The phototoxicity of an...