1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)

greener alternative

>95% in F+ active

N-Chloromethyl-N′-fluorotriethylenediammonium bis(tetrafluoroborate), F-TEDA
Empirical Formula (Hill Notation):
CAS Number:
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reaction suitability

reagent type: oxidant
reaction type: C-H Activation

greener alternative product characteristics

Learn more about the Principles of Green Chemistry.


>95% in F+ active


260 °C (lit.)

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a fluorine donor also called Selectfluor and has been enhanced for catalysis. Find details here.


1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) is an electrophilic fluorinating reagent used for greener fluorination of acetoacetamides in PEG-400.
Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400

It can be used:
  • As a highly effective and versatile source of electrophilic fluorine.
  • As a fluorinating reagent that effects oxidative ring opening of 2,5-diarylfurans to cis-1,4-enediones.
  • For direct fluorination of silyl ketene acetals leading to the formation of α-fluoro-α-arylcarboxylic acids.
  • As an electrophilic fluorinating reagent used. e.g. in the preparation of fluorinated acylsilanes.


5, 25, 100 g in poly bottle


A review.


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Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN 3088 4.2 / PGII

WGK Germany


Certificate of Analysis
Certificate of Origin
Rajendra P Singh et al.
Accounts of chemical research, 37(1), 31-44 (2004-01-21)
Synthetic and structural aspects of organofluorine compounds continue to be the focal points of vigorous research activities, as evidenced by the appearance of a large number of publications. Among the various useful methodologies for the introduction of fluorine into organic...
Oxidative ring opening of 2, 5-diarylfurans by Selectfluor
Blank SJ and Stephens CE
Tetrahedron Letters, 47(38), 6849-6850 (2006)
A novel general method for preparation of a-fluoro-a-arylcarboxylic acid. Direct fluorination of silyl ketene acetals with Selectfluor
Zhang F and Song JZ
Tetrahedron Letters, 47(43), 7641-7644 (2006)
Paul T Nyffeler et al.
Angewandte Chemie (International ed. in English), 44(2), 192-212 (2004-12-04)
The replacement of hydrogen atoms with fluorine substituents in organic substrates is of great interest in synthetic chemistry because of the strong electronegativity of fluorine and relatively small steric footprint of fluorine atoms. Many sources of nucleophilic fluorine are available...
A general method for synthesis of trifluoroacetyltrialkyl (aryl) silanes and the Sakurai reaction of fluorinated acylsilanes with allyl silanes
Chung WJ and Welch JT
Journal of Fluorine Chemistry, 125(4), 543-548 (2004)
The importance of selectively fluorinating compounds in medicinal chemistry, biology, and organic synthesis is well appreciated and provides a major impetus to the discovery of new and mild fluorinating agents that can operate safely and efficiently.
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