Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

440140

Sigma-Aldrich

(3-Aminopropyl)triethoxysilane

(3-Aminopropyl)triethoxysilane

99%

Synonym(s):

3-Triethoxysilylpropylamine, APTES, APTS

Sign Into View Organizational & Contract Pricing

Select a Size

100 ML
$93.60
500 ML
$357.00

$93.60

List Price$104.00Save 10%
Web-Only Promotion

Available to ship onMay 15, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
100 ML
$93.60
500 ML
$357.00

About This Item

Linear Formula:
H2N(CH2)3Si(OC2H5)3
CAS Number:
919-30-2
Molecular Weight:
221.37
Beilstein/REAXYS Number:
1754988
EC Number:
213-048-4
MDL number:
MFCD00008207
UNSPSC Code:
12352103
PubChem Substance ID:
24867571
NACRES:
NA.23

$93.60

List Price$104.00Save 10%
Web-Only Promotion

Available to ship onMay 15, 2025Details

Request a Bulk Order

Quality Level

200

assay

99%

form

liquid

bp

217 °C/760 mmHg (lit.)

density

0.946 g/mL at 25 °C (lit.)

SMILES string

CCO[Si](CCCN)(OCC)OCC

InChI

1S/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3

InChI key

WYTZZXDRDKSJID-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

(3-Aminopropyl)tiethoxysilane (APTES) is used as an amino-silane which is mainly used as a dispersant. APTES attaches an amino group to the functional silane for bio-conjugation.[1][2]

Application

Forms aminopropyl derivative of glass, an adsorbent for affinity chromatography. Used to prepare positively charged slides suitable for use with various immunohistochemical and in situ hybridization procedures.[3] Recently (3-Aminopropyl)triethoxysilane has been used to prepare dye-doped silica nanoparticles with minimal aggregation and minimal nonspecific binding with biomolecules.[4]
Self-assembled monolayer (SAM) of APTES can be used to improve the adhesion of graphene flakes and SiO2 to enable better contact with the metal electrodes. These electrodes may be used as electro-responsive tools for bio-sensing applications.[5] It can be used to functionalize silane diazirine for fiber optic biosensor application.[6] Hollow microcarriers (HMCs) can be surface modified with APTES which may be used for regenerative medicines and recombinant cells in biopharmaceutical industries.[7]
Used in a preparation of a series of tenary composite films of polyimide/SiO/polydiphenylsiloxane with good optical transparency.[8]

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 1

flash_point_f

199.4 °F - closed cup

flash_point_c

93 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCX7323
MKCX3692
WXBF3340V
MKCW1275
WXBF4265V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Effect of divalent versus monovalent cations on the MS2 retention capacity of amino-functionalized ceramic filters.
Bartels J, et al.
Physical Chemistry Chemical Physics, 20(16), 11215-11223 (2018)
Platinum nanoparticles homogenously decorating multilayered reduced graphene oxide for electrical nanobiosensor applications.
Proa-Coronado, et al.
Thin Solid Films, 658(1), 54-60 (2018)
Hollow microcarriers for large-scale expansion of anchorage-dependent cells in a stirred bioreactor.
YekrangSafakar, et al.
Biotechnology and Bioengineering, 115(7), 1717-1728 (2018)
Polymer International, 55, 1277-1277 (2006)
Functionalisation of Detonation Nanodiamond for Monodispersed, Soluble DNA-Nanodiamond Conjugates Using Mixed Silane Bead-Assisted Sonication Disintegration.
Edgington, et al.
Scientific Reports, 8(1), 728-728 (2018)
View All Related Papers

Articles

Functionalized Graphene Oxide: Properties & Applications

Professor Aran discusses engineering graphene-based materials through careful functionalization, enabling diverse applications.

1 Review This action will navigate to reviews.

Questions

1–10 of 13 Questions  

  1. Do you have any indications of what mass proportion I should use so that functionalization occurs between 3-APTES and an inorganic material, such as graphite?

    1 answer

    1. Typically, a mass proportion of 1-2 wt% of APTES is recommended for effective functionalization. However, please note that APTES may not effectively bind to pristine graphite, and surface modification of the graphite may be necessary to enhance the functionalization process.

      Helpful?

  2. Kann APTES eine dauerhafte chemische Bindung mit der Oberfläche von fused silica eingehen? Falls ja, durch welchen Mechanismus erfolgt die Anbindung an das Siliziumdioxid? Wir möchten es als Haftvermittler für eine CYTOP-Beschichtung verwenden.

    1 answer

    1. Yes, APTES can bond with fused silica. Fused silica, like silica gel, has hydroxyl (–OH) groups on its surface. When APTES is introduced to the fused silica surface, it undergoes hydrolysis. The ethoxy groups (–OEt) in APTES react with water, forming silanol groups (–Si–OH). The newly formed silanol groups can then react with the hydroxyl groups on the fused silica surface. This reaction leads to the formation of siloxane bonds (–Si–O–Si–), resulting in a covalent attachment of APTES to the fused silica.

      Helpful?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  5. Bonjour, Comment pouvons nous prélever l'APTES sans détériorer le produit?

    1 answer

    1. 440140 is a neat material of (3-Aminopropyl)triethoxysilane (APTES). As per Section 7 of SDS: https://www.sigmaaldrich.com/sds/aldrich/440140?userType=anonymous, it is recommended to handle the material in inert gas environment.

      Helpful?

  6. what is the minimum coverage of this silane (m2/g)?

    1 answer

    1. Unfortunately, there is no information on the minimum coverage of this material. It would depend on the coating method, including solvent, temperature, etc.

      Helpful?

  7. Can this product be used to silanize a surface by using silane deposition via gas-phase evaporation?

    1 answer

    1. This material has not been tested for use in silane deposition. APTES is referenced in the literature frequently in the vapor phase deposition of biosensors. The suitability would have to be determined experimentally.
      Please see the links below to review examples of this process:
      https://www.mdpi.com/2079-6374/13/1/36
      https://pubs.acs.org/doi/10.1021/acs.langmuir.8b01044

      Helpful?

  8. Does this solution have an expiry date?

    1 answer

    1. This product is assigned an expiration date of 2 years from the quality release date. Expiration dates are lot specific and printed on the label as well as the Certificate of Analysis. Please see the link below to review a sample Certificate of Analysis: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/440140-BULKMKCT8021.pdf

      Helpful?

  9. What is the viscosity of Product 440140, APTES (3-Aminopropyl)triethoxysilane)?

    1 answer

    1. According to our supplier’s information the viscosity is 1.6 cS.

      Helpful?

  10. How should Product 440140, APTES (3-Aminopropyl)triethoxysilane) be stored?

    1 answer

    1. We would recommend storing this product in accordance with our MSDS, which recommends storing at room temperature and under inert gas since this product is moisture sensitive.

      Helpful?

1–10 of 13 Questions  

Reviews

Active Filters

  1. 1 Ratings-Only Review

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service