The methoxy groups of the silane hydrolyze and form strong covalent bonds with the native oxide layers present on ceramics (SiO2) or free (OH) groups on silicon carbide or boron carbide. To improve adhesion at the interface, introducing controlled roughening of the surface is advisable. A solution concentration in the range of 1–5% should provide sufficient effectiveness.
440167
(3-Glycidyloxypropyl)trimethoxysilane
≥98%
Synonym(s):
3-(2,3-Epoxypropoxy)propyltrimethoxysilane, GLYMO, Glycidyl 3-(trimethoxysilyl)propyl ether
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Size/SKU | Availability | Price |
|---|---|---|
100 mL | Available to ship TODAYfromMILWAUKEE | $110.00 |
500 mL | Available to ship TODAYfromMILWAUKEE | $367.00 |
1 L | Available to ship TODAYfromMILWAUKEE | $627.00 |
About This Item
Empirical Formula (Hill Notation):
C9H20O5Si
CAS Number:
Molecular Weight:
236.34
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
219-784-2
Beilstein/REAXYS Number:
4308125
MDL number:
$110.00
Available to ship TODAYDetails
Subscriptions are currently unavailable.
Ships Every 4 weeks
Quality Segment
assay
≥98%
form
liquid
refractive index
n
bp
120 °C/2 mmHg (lit.)
density
1.07 g/mL at 25 °C (lit.)
SMILES string
CO[Si](CCCOCC1CO1)(OC)OC
InChI
1S/C9H20O5Si/c1-10-15(11-2,12-3)6-4-5-13-7-9-8-14-9/h9H,4-8H2,1-3H3
InChI key
BPSIOYPQMFLKFR-UHFFFAOYSA-N
General description
(3-Glycidyloxypropyl)trimethoxysilane (GPTMS) is a high-purity, bifunctional organosilane designed for the seamless integration of biological molecules and organic polymers with inorganic substrates. This ≥98% purity grade is unique for its terminal epoxy (oxirane) ring, which enables "reagent-free" covalent bioconjugation via nucleophilic attack from amines, thiols, or hydroxyls. This reagent is the gold standard for stabilizing conductive polymers and creating 3D-networked hybrid scaffolds, offering a pH-selective reactivity profile that allows for controlled surface modification and superior optical clarity in thin-film applications.
Application
As a versatile molecular bridge, GPTMS is essential for engineering intelligent interfaces and stimuli-responsive systems that enable precise interactions at the intersection of nanotechnology, biology, and electronics.
• Reagent-Free Bioconjugation: Enables direct immobilization of proteins, enzymes, and amino-modified DNA onto surfaces without secondary cross-linkers like EDC/NHS. • Conductive Polymer Stabilization: Enhances the electrical stability and mechanical adhesion of PEDOT:PSS films in bio-electronic sensors and neural interfaces. • Tissue Engineering Scaffolds: Functions as a critical cross-linker in chitosan-silica hybrids, significantly improving mechanical stability and biomineralization for bone regeneration. • Nanocarbon Reinforcement: Surface-modifies carbon nanotubes (MWCNTs) to optimize dispersion and interfacial bonding in high-performance nanocomposites for medical implants. • Enzyme Immobilization: Functionalizes silica and magnetic nanoparticles to create high-surface-area biocatalytic platforms for diagnostic assays and pharmaceutical synthesis.
• Reagent-Free Bioconjugation: Enables direct immobilization of proteins, enzymes, and amino-modified DNA onto surfaces without secondary cross-linkers like EDC/NHS. • Conductive Polymer Stabilization: Enhances the electrical stability and mechanical adhesion of PEDOT:PSS films in bio-electronic sensors and neural interfaces. • Tissue Engineering Scaffolds: Functions as a critical cross-linker in chitosan-silica hybrids, significantly improving mechanical stability and biomineralization for bone regeneration. • Nanocarbon Reinforcement: Surface-modifies carbon nanotubes (MWCNTs) to optimize dispersion and interfacial bonding in high-performance nanocomposites for medical implants. • Enzyme Immobilization: Functionalizes silica and magnetic nanoparticles to create high-surface-area biocatalytic platforms for diagnostic assays and pharmaceutical synthesis.
1 of 1
This Item | |||
|---|---|---|---|
| density 1.07 g/mL at 25 °C (lit.) | density 1.004 g/mL at 20 °C (lit.) | density 1.057 g/mL at 25 °C (lit.) | density 1.09 g/mL at 25 °C (lit.) |
| refractive index n | refractive index n | refractive index n | refractive index n |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| bp 120 °C/2 mmHg (lit.) | bp - | bp 213-215 °C (lit.) | bp 195 °C/750 mmHg (lit.) |
| assay ≥98% | assay ≥97.0% (GC) | assay 95% | assay ≥97% |
| form liquid | form - | form liquid | form liquid |
Still not finding the right product?
Explore all of our products under (3-Glycidyloxypropyl)trimethoxysilane
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 3 - Eye Dam. 1
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
-
Ist das Produkt geeignet, um die Verklebungsfestigkeiten von Epoxid auf keramischen Oberflächen (gesintertes oder reaktionsgebundenes Siliziumkarbid bzw. Borkarbid) zu verbessern?
1 answer-
Helpful?
-
-
How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
-
-
How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
-
-
I would like to know the solvent for GPTMS. What solvents does GPTMS dispersed in?
1 answer-
This product is supplied as a neat or pure liquid with a density of 1.07 g/mL. The minimum purity is 98%. This compound is soluble in water, alcohols, acetone, and most aliphatic esters at normal application levels of 45%.
Helpful?
-
-
I connected GPTMS synthetically to my lipid(APTES), now my lipid cannot be dissolved in chloroform, ethanol and methanol solutions, which was previously dissolved, what solvent should I use?
1 answer-
The solubility of the GPTMS/APTES sample has not been tested, however decreasing the concentration in chloroform may be useful. Other solvents such as oils (see C8267) or a strong base, such as sodium hydroxide, may also be an option. See the link below to a publication that may be of interest:
https://pubs.acs.org/doi/10.1021/acssuschemeng.9b06741If you have any further issues, please contact https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section, and provide the required information so that a member of the Technical Service team can reach out to assist further. Thank you.
Helpful?
-
-
Where can I find more detailed information about how to use Product 440167. 3-Glycidyloxypropyl)trimethoxysilane, GLYMO, in adhesion/reinforcement applications?
1 answer-
Dow Corning® has published a technical bulletin on this product, which is available by calling Technical Service at 800-231-8327.
Helpful?
-
-
Is Product 440167 (3-Glycidyloxypropyl)trimethoxysilane GLYMO, equivalent to Dow's Z-6040?
1 answer-
Yes. This listing is manufactured by Dow Corning Corporation and distributed by Sigma-Aldrich.
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-
-
What is the viscosity of Product 440167 (3-Glycidyloxypropyl)trimethoxysilane GLYMO?
1 answer-
This material is a low viscosity liquid with an average value of about 3 centistokes. Please note that this value is not part of our specifications.
Helpful?
-
-
What can Product 440167, 3-Glycidyloxypropyl)trimethoxysilane GLYMO, be used for?
1 answer-
According to Dow Corning®, 3-GLYCIDOXYPROPYLTRIMETHOXYSILANE can be used as a coupling agent for many thermoset resins with glass or mineral fillers. Specifically, it has been used as a reinforcement treatment on glass fiber to improve physical properties (especially wet strength) or as an adhesion promoter to improve the bonding of a polymer coating or adhesive to glass, metals or other polymeric surfaces.
Helpful?
-