reagent grade, ≥99%

Bis(trimethylsilyl)amine, HMDS
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


reagent grade





refractive index

n20/D 1.407 (lit.)


125 °C (lit.)

SMILES string




InChI key


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General description

Hexamethyldisilazane (HMDS) is used to trimethylsilylate alcohols, amines, thiols. HMDS can also be used for the preparation of trimethylsilyl ethers from hydroxy compounds.


HMDS is used for specimen preparation for scanning electron microscopy.


1 L in Sure/Seal™
100 mL in Sure/Seal™

Signal Word


Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN 1992 6.1(3) / PGII

WGK Germany


Flash Point(F)

52.5 °F - closed cup

Flash Point(C)

11.4 °C - closed cup

Certificate of Analysis

Certificate of Origin

F Braet et al.
Journal of microscopy, 186(Pt 1), 84-87 (1997-04-01)
Critical point drying (CPD) is a common method of drying biological specimens for scanning electron microscopy (SEM). Drying by evaporation of hexamethyldisilazane (HMDS) has been described as a good alternative. This method, however, is infrequently used. Therefore, we reassessed HMDS...
Rapid and highly efficient trimethylsilylation of alcohols and phenols
with hexamethyldisilazane (HMDS) catalysed by in situ generated I2
using OxoneR /KI or cerium ammonium nitrate (CAN)/KI systems
under mild conditions
Eskandar K, et al.
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