452920

Sigma-Aldrich

Trimethyl borate

≥98%

Synonym(s):
Boric acid trimethyl ester, Methyl borate
Linear Formula:
B(OCH3)3
CAS Number:
Molecular Weight:
103.91
Beilstein/REAXYS Number:
1697939
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

vapor density

3.59 (vs air)

assay

≥98%

refractive index

n20/D 1.346 (lit.)

bp

68-69 °C (lit.)

mp

−34 °C (lit.)

density

0.932 g/mL at 20 °C (lit.)

SMILES string

COB(OC)OC

InChI

1S/C3H9BO3/c1-5-4(6-2)7-3/h1-3H3

InChI key

WRECIMRULFAWHA-UHFFFAOYSA-N

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Application

Trimethyl borate reacts with a Grignard reagent or organolithium compounds to yield dimethyl boronates, which upon subsequent aqueous acid treatment afford corresponding boronic acids. The resultant boronic acids or esters are useful intermediates in various cross-coupling reactions such as Suzuki coupling and Chan-Lam coupling. It is also used in the preparation of sodium borohydride.

Packaging

100, 500 mL in Sure/Seal™
2 L in Sure/Seal™

Legal Information

ASCENSUS product

Signal Word

Danger

Target Organs

Eyes

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2416 3 / PGII

WGK Germany

WGK 1

Flash Point(F)

12.2 °F - (own results)

Flash Point(C)

-11 °C - (own results)

New N-and O-arylations with phenylboronic acids and cupric acetate.
Chan D M, et al.
Tetrahedron Letters, 39(19), 2933-2936 (1998)
The Preparation of Sodium Borohydride by the High Temperature Reaction of Sodium Hydride with Borate Esters1.
Schlesinger H I, et al.
Journal of the American Chemical Society, 75(1), 205-209 (1953)
Cross?Coupling Reactions Of Organoboranes: An Easy Way To Construct C-C Bonds (Nobel Lecture)
Suzuki A
Angewandte Chemie (International Edition in English), 50(30), 6722-6737 (2011)
Boronic esters in stereodirected synthesis.
Matteson D S
Tetrahedron, 45(7), 1859-1885 (1989)
Palladium-catalyzed cross-coupling reactions of organoboron compounds.
Miyaura N and Suzuki A
Chemical Reviews, 95(7), 2457-2483 (1995)
Related Content
Our laboratory is interested in the development of new synthetic methodology and its application to the synthesis of potentially useful molecules. Our research work is spread across a wide range of different areas including transition-metal catalysis (gold, palladium), organoboron chemistry, organocatalysis, multicomponent reactions, and sustainable chemistry.
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