461075

Sigma-Aldrich

1-(Trimethylsilyl)-2-pyrrolidinone

96%

Empirical Formula (Hill Notation):
C7H15NOSi
CAS Number:
Molecular Weight:
157.29
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

96%

refractive index

n20/D 1.46 (lit.)

bp

90 °C/20 mmHg (lit.)

density

0.983 g/mL at 25 °C (lit.)

SMILES string

C[Si](C)(C)N1CCCC1=O

InChI

1S/C7H15NOSi/c1-10(2,3)8-6-4-5-7(8)9/h4-6H2,1-3H3

InChI key

LUBVCBITQHEVCJ-UHFFFAOYSA-N

General description

1-(Trimethylsilyl)-2-pyrrolidinone has been prepared by refluxing a mixture of 2-pyrrolidinone, triethylamine and trimethylchlorosilane in benzene. It undergoes sulfenylation with phenyl disulfide to form the corresponding bissulfide as the major product.

Application

1-(Trimethylsilyl)-2-pyrrolidinone may be used for the preparation of 1-(diphenylphosphonio)pyrrolidin-2-one and 1-(1-adamantylcarbonyl)-2-pyrrolidinone.

Packaging

10 mL in glass bottle

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 1993C 3 / PGIII

WGK Germany

WGK 3

Flash Point(F)

127.4 °F - closed cup

Flash Point(C)

53 °C - closed cup

Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2.
Kolocouris N, et al.
Journal of Medicinal Chemistry, 39(17), 3307-3318 (1996)
Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles.
Setaki D, et al.
Bioorganic Chemistry, 34(5), 248-273 (2006)
Sulfenylation and sulfinylation of lactams and imino ethers.
Zoretic PA, et al.
The Journal of Organic Chemistry, 43(7), 1379-1382 (1978)
Efficient method for the preparation of carboxylic acid alkyl esters or alkyl phenyl ethers by a new-type of oxidation-reduction condensation using 2, 6-dimethyl-1, 4-benzoquinone and alkoxydiphenylphosphines.
Shintou T, et al.
Bulletin of the Chemical Society of Japan, 76(8), 1645-1667 (2003)

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