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MilliporeSigma

465119

Sigma-Aldrich

Baicalein

98%

Synonym(s):

5,6,7-Trihydroxyflavone

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100 MG
$51.40
500 MG
$163.00

About This Item

Empirical Formula (Hill Notation):
C15H10O5
CAS Number:
Molecular Weight:
270.24
Beilstein/REAXYS Number:
272683
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

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$51.40


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Quality Level

assay

98%

form

solid

mp

256-271 °C (lit.)

functional group

ketone
phenyl

SMILES string

Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

InChI key

FXNFHKRTJBSTCS-UHFFFAOYSA-N

Gene Information

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This Item
19632292081PHL89577
Baicalein 98%

465119

Baicalein

Baicalein A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀= 120 nM) and reverse transcriptase.

196322

Baicalein

Baicalein analytical standard

92081

Baicalein

assay

98%

assay

≥98% (HPLC)

assay

≥95.0% (HPLC)

assay

≥95.0% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

mp

256-271 °C (lit.)

mp

-

mp

256-271 °C (lit.)

mp

256-271 °C (lit.)

form

solid

form

solid

form

-

form

solid

functional group

ketone

functional group

-

functional group

-

functional group

-

Gene Information

mouse ... Hexa(15211)
rat ... Alox15(81639), Alox5(25290)

Gene Information

-

Gene Information

-

Gene Information

-

General description

Baicalein, a flavonoid, is a xanthine oxidase inhibitor.[1] Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.[2]

Application

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.[3]

Biochem/physiol Actions

The flavonoid component of Nepalese and Sino-Japanese crude drugs.[4][5] Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. At what percentage of DMso baicalein and naringin will be dissolved?

    1 answer
    1. Baicalein and can be soluble in 20mg/ml DMSO. Naringin can be soluble in 10 mg/ml neat DMSO.

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